| Gene Name | CD320 |
| HF Protein Name | Uncharacterized protein |
| HF Function | Essential for viral entry |
| Uniprot ID | E1C645 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 420066 |
| Host Factor (HF) Name in Paper | TVA |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSGALG00000000629 |
| Ensemble Transcript | ENSGALT00000000895 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005747, GO:0006120, GO:0008137, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | N.A. |
| PANTHER ID | PTHR12485 |
| PDB ID(s) | N.A., |
| pfam ID | PF07347, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Gallus gallus (Chicken) |
| Virus Name | Avian leukosis virus |
| Virus Short Name | ALV |
| Order | Unassigned |
| Virus Family | Retroviridae |
| Virus Subfamily | Orthoretrovirinae |
| Genus | Alpharetrovirus |
| Species | Avian leukosis virus |
| Host | Vertebrates |
| Cell Tropism | N.A. |
| Associated Disease | Malignancies |
| Mode of Transmission | N.A. |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/161/retroviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Retroviridae |
| Paper Title | Binding of more than one Tva800 molecule is required for ASLV-A entry |
| Author's Name | Eleanor R Gray, Christopher JR Illingworth, John M Coffin and Jonathan P Stoye |
| Journal Name | Retrovirology |
| Pubmed ID | 22099981 |
| Abstract | BACKGROUND:Understanding the mechanism by which viruses enter their target cell is an essential part of understanding their infectious cycle. Previous studies have focussed on the multiplicity of viral envelope proteins that need to bind to their cognate receptor to initiate entry. Avian sarcoma and leukosis virus Envelope protein (ASLV Env) mediates entry via a receptor, Tva, which can be attached to the cell surface either by a phospholipid anchor (Tva800) or a transmembrane domain (Tva950). In these studies, we have now investigated the number of target receptors necessary for entry of ASLV Env-pseudotyped virions. RESULTS: Using titration and modelling experiments we provide evidence that binding of more than one receptor, probably two, is needed for entry of virions via Tva800. However, binding of just one Tva950 receptor is sufficient for successful entry. CONCLUSIONS: The different modes of attachment of Tva800 and Tva950 to the cell membrane have important implications for the utilisation of these proteins as receptors for viral binding and/or uptake. |
| Used Model | MDTF cells |
| DOI | 10.1186/1742-4690-8-96 |
