Download Help

Virus Details


VHFID1572

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name NCOA2
HF Protein Name Nuclear receptor coactivator 2
HF Function Involved in Borna Disease Virus cell entry
Uniprot ID Q15596
Protein Sequence View Fasta Sequence
NCBI Gene ID 10499
Host Factor (HF) Name in Paper NCOA2
Gene synonyms BHLHE75 SRC2 TIF2
Ensemble Gene ID ENSG00000140396
Ensemble Transcript ENST00000452400
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000978, GO:0001162, GO:0003682, GO:0003713, GO:0005634, GO:0005654, GO:0005737, GO:0006351, GO:0006355, GO:0010906, GO:0015721, GO:0016604, GO:0016922, GO:0017162, GO:0019216, GO:0019904, GO:0030374, GO:0030375, GO:0030522, GO:0032870, GO:0032922, GO:0032991, GO:0035257, GO:0045475, GO:0045944, GO:0046983, GO:1904017,
MINT ID Q15596
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 601993
PANTHER ID PTHR10684;PTHR10684:SF2
PDB ID(s) 1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23, 2FAI, 2G44, 2G5O, 2LDC, 2P15, 2P1T, 2P1U, 2P1V, 2Q7J, 2Q7L, 2YJD, 2ZXZ, 2ZY0, 3A9E, 3CLD, 3DZU, 3DZY, 3E00, 3E7C, 3E94, 3ERD, 3FUG, 3GN8, 3K22, 3K23, 3KWY, 3KYT, 3L0E, 3L0J, 3L0L, 3O1D, 3O1E, 3OAP, 3OZJ, 3PCU, 3PLZ, 3Q95, 3R5M, 3UP0, 3UP3, 4CSJ, 4DOS, 4E2J, 4FHH, 4FHI, 4IA1, 4IA2, 4IA3, 4IA7, 4IQR, 4IU7, 4IUI, 4IV2, 4IV4, 4IVW, 4IVY, 4IW6, 4IW8, 4IWC, 4IWF, 4K4J, 4K6I, 4M8E, 4M8H, 4NIE, 4NQA, 4OC7, 4P6W, 4P6X, 4PLD, 4PLE, 4POH, 4POJ, 4PP3, 4PP5, 4PP6, 4PPP, 4PPS, 4PXM, 4Q0A, 4Q13, 4QE6, 4QE8, 4RFW, 4RMC, 4RMD, 4RME, 4RUO, 4UDC, 4UDD, 4WG0, 4ZN7, 4ZN9, 4ZNH, 4ZNS, 4ZNT, 4ZNU, 4ZNV, 4ZNW, 4ZO1, 4ZSH, 5APH, 5APJ, 5DI7, 5DID, 5DIE, 5DIG, 5DK9, 5DKB, 5DKE, 5DKG, 5DKS, 5DL4, 5DLR, 5DMC, 5DMF, 5DP0, 5DRJ, 5DRM, 5DTV, 5DU5, 5DUE, 5DUG, 5DUH, 5DVS, 5DVV, 5DWE, 5DWG, 5DWI, 5DWJ, 5DX3, 5DXB, 5DXE, 5DXG, 5DXK, 5DXM, 5DXP, 5DXQ, 5DXR, 5DY8, 5DYB, 5DYD, 5DZ0, 5DZ1, 5DZ3, 5DZH, 5DZI, 5E0W, 5E0X, 5E14, 5E15, 5E19, 5E1C, 5EC9, 5EGV, 5EHJ, 5EI1, 5EIT, 5G3J, 5G42, 5G43, 5G44, 5G45, 5G46, 5G5W, 5H1E, 5HYR, 5I4V, 5IAW, 5ICK, 5KCC, 5KCD, 5KCE, 5KCF, 5KCT, 5KCU, 5KCW, 5KD9, 5KR9, 5KRA, 5KRC, 5KRF, ,
pfam ID PF07469, PF16279, PF08815, PF00989, PF08832,
Drug Bank ID DB06871, DB07863, DB07708, DB07712, DB01645, DB02998, DB08773, DB08601,
ChEMBL ID N.A.
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Borna disease virus
Virus Short Name BDV
Order Mononegavirales
Virus Family Bornaviridae
Virus Subfamily N.A.
Genus Bornavirus
Species Borna disease virus
Host Horses, sheep, cattle, rodents, birds, sometimes human also
Cell Tropism Neurons and astrocytes, also infect oligodendrocytes and ependymal cells
Associated Disease Borna disease ( in mammals), encephalitis, proventricular dilatation disease (in birds)
Mode of Transmission Direct contact with salivary, urine and feces
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/195/bornaviridae
Virus Host DB link N.A.

Publication Information

Paper Title Identification of host factors involved in borna disease virus cell entry through a small interfering RNA functional genetic screen
Author's Name Roberto Clemente, Eugene Sisman, Pedro Aza-Blanc and Juan C. de la Torre
Journal Name Journal Of Virology
Pubmed ID 20071576
Abstract Borna disease virus (BDV), the prototypic member of the Bornaviridae family, within the order Mononegavirales, is highly neurotropic and constitutes an important model system for the study of viral persistence in the central nervous system (CNS) and associated disorders. The virus surface glycoprotein (G) has been shown to direct BDV cell entry via receptor-mediated endocytosis, but the mechanisms governing cell tropism and propagation of BDV within the CNS are unknown. We developed a small interfering RNA (siRNA)-based screening to identify cellular genes and pathways that specifically contribute to BDV G-mediated cell entry. Our screen relied on silencing-mediated increased survival of cells infected with rVSVDeltaG*/BDVG, a cytolytic recombinant vesicular stomatitis virus expressing BDV G that mimics the cell tropism and entry pathway of bona fide BDV. We identified 24 cellular genes involved in BDV G-mediated cell entry. Identified genes are known to participate in a broad range of distinct cellular functions, revealing a complex process associated with BDV cell entry. The siRNA-based screening strategy we have developed should be applicable to identify cellular genes contributing to cell entry mediated by surface G proteins of other viruses.
Used Model Ol cells
DOI 10.1128/JVI.02274-09