| Gene Name | RBMX |
| HF Protein Name | RNA-binding motif protein, X chromosome |
| HF Function | Required for the maintenance of virus nuclear viral factories |
| Uniprot ID | P38159 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 27316 |
| Host Factor (HF) Name in Paper | RBMX |
| Gene synonyms | HNRPG RBMXP1 |
| Ensemble Gene ID | ENSG00000147274 |
| Ensemble Transcript | ENST00000320676 [P38159-1];ENST00000431446 [P38159-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000381, GO:0000398, GO:0001047, GO:0001649, GO:0003682, GO:0003723, GO:0003727, GO:0003729, GO:0005615, GO:0005634, GO:0005654, GO:0005719, GO:0006366, GO:0006376, GO:0006509, GO:0016020, GO:0016070, GO:0019904, GO:0030529, GO:0042802, GO:0044530, GO:0045944, GO:0048025, GO:0048026, GO:0051259, GO:0051260, GO:0070062, GO:0071013, GO:0071347, |
| MINT ID | P38159 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 300199 |
| PANTHER ID | N.A. |
| PDB ID(s) | 2MB0, 2MKS, |
| pfam ID | PF08081, PF00076, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Borna disease virus |
| Virus Short Name | BDV |
| Order | Mononegavirales |
| Virus Family | Bornaviridae |
| Virus Subfamily | N.A. |
| Genus | Bornavirus |
| Species | Borna disease virus |
| Host | Horses, sheep, cattle, rodents, birds, sometimes human also |
| Cell Tropism | Neurons and astrocytes, also infect oligodendrocytes and ependymal cells |
| Associated Disease | Borna disease ( in mammals), encephalitis, proventricular dilatation disease (in birds) |
| Mode of Transmission | Direct contact with salivary, urine and feces |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/negative-sense-rna-viruses-2011/w/negrna_viruses/195/bornaviridae |
| Virus Host DB link | N.A. |
| Paper Title | X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virusnuclear viral factories |
| Author's Name | Yuya Hirai, Tomoyuki Honda, Akiko Makino, Yuzo Watanabe and Keizo Tomonaga |
| Journal Name | Journal Of General Virology |
| Pubmed ID | 26333388 |
| Abstract | Borna disease virus (BDV) is a non-segmented, negative-strand RNA virus that establishes persistent infection in the nucleus. Although BDV forms viral inclusion bodies, termed viral speckles of transcripts (vSPOTs), which are associated with chromatin in the nucleus, the host factors involved in the maintenance of vSPOTs remain largely unknown. In this study, we identified X-linked RNA-binding motif protein (RBMX) as a nuclear factor interacting with BDV nucleoprotein. Interestingly, knockdown of RBMX led to disruption of the formation of vSPOTs and reduced both transcription and replication of BDV. Our results indicate that RBMX is involved in the maintenance of the structure of the virus factory in the nucleus. |
| Used Model | OL cells |
| DOI | 10.1099/jgv.0.000273 |
