Virus Details


VHFID1585

Host Factor Information

Gene Name CDK2
HF Protein Name Cyclin-dependent kinase 2
HF Function Essential for viral replication
Uniprot ID P24941
Protein Sequence View Fasta Sequence
NCBI Gene ID 1017
Host Factor (HF) Name in Paper Cdk2 kinase
Gene synonyms CDKN2
Ensemble Gene ID ENSG00000123374
Ensemble Transcript ENST00000266970 [P24941-1];ENST00000354056 [P24941-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000082, GO:0000086, GO:0000122, GO:0000307, GO:0000781, GO:0000793, GO:0000805, GO:0000806, GO:0004674, GO:0004693, GO:0005524, GO:0005634, GO:0005654, GO:0005667, GO:0005737, GO:0005768, GO:0005813, GO:0005829, GO:0006260, GO:0006281, GO:0006468, GO:0006813, GO:0006977, GO:0007099, GO:0007265, GO:0007275, GO:0008284, GO:0010033, GO:0010389, GO:0015030, GO:0016301, GO:0016572, GO:0018105, GO:0019904, GO:0030332, GO:0031571, GO:0032298, GO:0045893, GO:0046872, GO:0051298, GO:0051301, GO:0051321, GO:0051436, GO:0051439, GO:0060968, GO:0071732, GO:0097123, GO:0097124, GO:0097134, GO:0097135, GO:0097472, GO:1901796,
MINT ID P24941
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 116953
PANTHER ID N.A.
PDB ID(s) 1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII, 1GIJ, 1GY3, 1GZ8, 1H00, 1H01, 1H07, 1H08, 1H0V, 1H0W, 1H1P, 1H1Q, 1H1R, 1H1S, 1H24, 1H25, 1H26, 1H27, 1H28, 1HCK, 1HCL, 1JST, 1JSU, 1JSV, 1JVP, 1KE5, 1KE6, 1KE7, 1KE8, 1KE9, 1OGU, 1OI9, 1OIQ, 1OIR, 1OIT, 1OIU, 1OIY, 1OKV, 1OKW, 1OL1, 1OL2, 1P2A, 1P5E, 1PF8, 1PKD, 1PW2, 1PXI, 1PXJ, 1PXK, 1PXL, 1PXM, 1PXN, 1PXO, 1PXP, 1PYE, 1QMZ, 1R78, 1URC, 1URW, 1V1K, 1VYW, 1VYZ, 1W0X, 1W8C, 1W98, 1WCC, 1Y8Y, 1Y91, 1YKR, 2A0C, 2A4L, 2B52, 2B53, 2B54, 2B55, 2BHE, 2BHH, 2BKZ, 2BPM, 2BTR, 2BTS, 2C4G, 2C5N, 2C5O, 2C5V, 2C5X, 2C5Y, 2C68, 2C69, 2C6I, 2C6K, 2C6L, 2C6M, 2C6O, 2C6T, 2CCH, 2CCI, 2CJM, 2CLX, 2DS1, 2DUV, 2EXM, 2FVD, 2G9X, 2HIC, 2I40, 2IW6, 2IW8, 2IW9, 2J9M, 2JGZ, 2R3F, 2R3G, 2R3H, 2R3I, 2R3J, 2R3K, 2R3L, 2R3M, 2R3N, 2R3O, 2R3P, 2R3Q, 2R3R, 2R64, 2UUE, 2UZB, 2UZD, 2UZE, 2UZL, 2UZN, 2UZO, 2V0D, 2V22, 2VTA, 2VTH, 2VTI, 2VTJ, 2VTL, 2VTM, 2VTN, 2VTO, 2VTP, 2VTQ, 2VTR, 2VTS, 2VTT, 2VU3, 2VV9, 2W05, 2W06, 2W17, 2W1H, 2WEV, 2WFY, 2WHB, 2WIH, 2WIP, 2WMA, 2WMB, 2WPA, 2WXV, 2X1N, 2XMY, 2XNB, 3BHT, 3BHU, 3BHV, 3DDP, 3DDQ, 3DOG, 3EID, 3EJ1, 3EOC, 3EZR, 3EZV, 3F5X, 3FZ1, 3IG7, 3IGG, 3LE6, 3LFN, 3LFQ, ,
pfam ID PF00069,
Drug Bank ID DB07054, DB07504, DB08463, DB07501, DB07137, DB08137, DB02603, DB04288, DB02297, DB06948, DB07982, DB08248, DB08309, DB02973, DB08241, DB08136, DB03307, DB08134, DB04407, DB07791, DB08572, DB07163, DB08132, DB02898, DB07612, DB08247, DB07203, DB08233, DB02407, DB02833, DB05037, DB06616, DB03496, DB02950, DB02052, DB03801, DB07790, DB06944, DB08768, DB08133, DB07936, DB02647, DB08677, DB08066, DB08135, DB07126, DB02116, DB04662, DB02733, DB02010, DB03428, DB04669,
ChEMBL ID CHEMBL301
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Bovine Papillomavirus Virus
Virus Short Name BPV
Order Unassigned
Virus Family Papillomaviridae
Virus Subfamily N.A.
Genus Epsilonpapillomavirus
Species Bovine papillomavirus 5
Host N.A.
Cell Tropism Epithelial cells of skin, mucous membranes
Associated Disease N.A.
Mode of Transmission Contact
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae

Publication Information

Paper Title Functional Interaction between the Bovine Papillomavirus Virus Type 1 Replicative Helicase E1 and Cyclin E-Cdk2
Author's Name NATHALIE CUEILLE, ROMAIN NOUGAREDE, FRANCISCA MECHALI, MICHEL PHILIPPE AND CATHERINE BONNE-ANDREA
Journal Name Journal Of Virology
Pubmed ID 9696820
Abstract We have found that the replicative helicase E1 of bovine papillomavirus type 1 (BPV-1) interacts with a key cell cycle regulator of S phase, the cyclin E-Cdk2 kinase. The E1 helicase, which interacts with cyclin E and not with Cdk2, presents the highest affinity for catalytically active kinase complexes. In addition, E1, cyclin E, and Cdk2 expressed in Xenopus egg extracts are quantitatively coimmunoprecipitated from crude extracts by either anti-Cdk2 or anti-E1 antibodies. E1 protein is also a substrate of the cyclin E-Cdk2 kinase in vitro. Using the viral components required for in vitro BPV-1 replication and free-membrane cytosol from Xenopus eggs, we show that efficient replication of BPV plasmids is dependent on the addition of E1-cyclin E-Cdk2 complexes. Thus, the BPV initiator of replication and cyclin E-Cdk2 are likely to function together as a protein complex which may be the key to the cell cycle regulation of papillomavirus replication.
Used Model N.A.
DOI N.A.