| Gene Name | HAVCR1 |
| HF Protein Name | Hepatitis A virus cellular receptor 1 |
| HF Function | Essential for viral entry |
| Uniprot ID | Q96D42 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 26762 |
| Host Factor (HF) Name in Paper | TIM1 |
| Gene synonyms | KIM1 TIM1 TIMD1 |
| Ensemble Gene ID | ENSG00000113249 |
| Ensemble Transcript | ENST00000339252;ENST00000523175 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0016021, GO:0031514, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 606518 |
| PANTHER ID | N.A. |
| PDB ID(s) | 5DZO, 5F70, |
| pfam ID | PF07686, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Dengue virus 2 |
| Virus Short Name | DENV 2 |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Dengue virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | Phagocytes, hepatocytes |
| Associated Disease | Dengue fever |
| Mode of Transmission | Arthropod bite, mainly mosquitoes |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry |
| Author's Name | Laurent Meertens, Xavier Carnec, Manuel Perera Lecoin, Rasika Ramdasi, Florence Guivel-Benhassine, Erin Lew, Greg Lemke, Olivier Schwartz, and Ali Amara |
| Journal Name | Cell PRESS |
| Pubmed ID | 23084921 |
| Abstract | Dengue viruses (DVs) are responsible for the most medically relevant arboviral diseases. However, the molecular interactions mediating DV entry are poorly understood. We determined that TIM and TAM proteins, two receptor families that mediate the phosphatidylserine(PtdSer)-dependent phagocytic removal of apoptotic cells, serve as DV entry factors. Cells poorly susceptible to DV are robustly infected after ectopic expression of TIM or TAM receptors. Conversely, DV infection of susceptible cells is inhibited by anti-TIM or anti-TAM antibodies or knockdown of TIM and TAM expression. TIM receptors facilitate DV entry by directly interacting with virion-associated PtdSer. TAM-mediated infection relies on indirect DV recognition, in which the TAM ligand Gas6 acts as a bridging molecule by binding to PtdSer within the virion. This dual mode of virus recognition by TIM and TAM receptors reveals how DVs usurp the apoptotic cell clearance pathway for infectious entry. |
| Used Model | HEK293T, CHO745 cells, Cos-7, A549, VERO, and Huh7 5.1 cells |
| DOI | 10.1016/j.chom.2012.08.009 |
