| Gene Name | KDELR2 |
| HF Protein Name | ER lumen protein-retaining receptor 2 |
| HF Function | Assists Dengue Virus exit from the Endoplasmic Reticulum |
| Uniprot ID | P33947 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 11014 |
| Host Factor (HF) Name in Paper | KDELR2 |
| Gene synonyms | ERD2.2 |
| Ensemble Gene ID | ENSG00000136240 |
| Ensemble Transcript | ENST00000258739 [P33947-1];ENST00000490996 [P33947-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000139, GO:0005046, GO:0005783, GO:0005789, GO:0005794, GO:0005801, GO:0006621, GO:0006886, GO:0006890, GO:0016021, GO:0030133, GO:0070062, |
| MINT ID | P33947 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 609024 |
| PANTHER ID | PTHR10585 |
| PDB ID(s) | N.A., |
| pfam ID | PF00810, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Dengue virus 2 |
| Virus Short Name | DENV 2 |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Dengue virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | Phagocytes, hepatocytes |
| Associated Disease | Dengue fever |
| Mode of Transmission | Arthropod bite, mainly mosquitoes |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | KDEL Receptors Assist Dengue Virus Exit from the Endoplasmic Reticulum |
| Author's Name | Ming Yuan Li, Marc Grandadam, Kevin Kwok, Thibault Lagache, Yu Lam Siu, Jing Shu Zhang, Kouxiong Sayteng, Mateusz Kudelko, Cheng Feng Qin, Jean-Christophe Olivo-Marin, Roberto Bruzzone and Pei Gang Wang |
| Journal Name | Cell PRESS |
| Pubmed ID | 25753416 |
| Abstract | Membrane receptors at the surface of target cells are key host factors for virion entry however, it is unknown whether trafficking and secretion of progeny virus requires host intracellular receptors. In this study, we demonstrate that dengue virus (DENV) interacts with KDEL receptors (KDELR), which cycle between the ER and Golgi apparatus, for vesicular transport from ER to Golgi. Depletion of KDELR by siRNA reduced egress of both DENV progeny and recombinant subviral particles (RSPs). Coimmunoprecipitation of KDELR with dengue structural protein prM required three positively charged residues at the N terminus, whose mutation disrupted protein interaction and inhibited RSP transport from the ER to the Golgi. Finally, siRNA depletion of class II Arfs, which results in KDELR accumulation in the Golgi, phenocopied results obtained with mutagenized prME and KDELR knockdown. Our results have uncovered a function for KDELR as an internal receptor involved in DENV trafficking. |
| Used Model | Vero E6 cells and HEK293T cells |
| DOI | 10.1016/j.celrep.2015.02.021 |
