| Gene Name | TRIM25 |
| HF Protein Name | E3 ubiquitin/ISG15 ligase TRIM25 |
| HF Function | Dengue subgenomic RNA binds to TRIM25 and inhibits intrferon production |
| Uniprot ID | Q14258 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 7706 |
| Host Factor (HF) Name in Paper | TRIM25 |
| Gene synonyms | EFP RNF147 ZNF147 |
| Ensemble Gene ID | ENSG00000121060 |
| Ensemble Transcript | ENST00000316881;ENST00000537230 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0003700, GO:0003723, GO:0004842, GO:0005654, GO:0005829, GO:0006511, GO:0006513, GO:0008270, GO:0016032, GO:0016579, GO:0016604, GO:0016874, GO:0019985, GO:0032480, GO:0033280, GO:0036503, GO:0043123, GO:0043627, GO:0045087, GO:0045296, GO:0046596, GO:0046597, GO:0051091, GO:0051092, GO:0051607, GO:0060333, GO:1902186, GO:1902187, GO:1904264, GO:1990830, |
| MINT ID | Q14258 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600453 |
| PANTHER ID | N.A. |
| PDB ID(s) | 4CFG, 4LTB, 5EYA, 5FER, |
| pfam ID | PF13765, PF00622, PF13445, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Dengue virus 2 |
| Virus Short Name | DENV 2 |
| Order | Unassigned |
| Virus Family | Flaviviridae |
| Virus Subfamily | N.A. |
| Genus | Flavivirus |
| Species | Dengue virus |
| Host | Human, mammals, mosquitoes and ticks |
| Cell Tropism | Phagocytes, hepatocytes |
| Associated Disease | Dengue fever |
| Mode of Transmission | Arthropod bite, mainly mosquitoes |
| VIPR DB link | http://www.viprbrc.org/brc/home.spg?decorator=flavi |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_online_report/positive-sense-rna-viruses/w/flaviviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Flaviviridae |
| Paper Title | Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness |
| Author's Name | Manokaran G, Finol E, Wang C, Gunaratne J, Bahl J, Ong EZ, Tan HC, Sessions OM, Ward AM, Gubler DJ, Harris E, Garcia-Blanco MA, Ooi EE |
| Journal Name | science |
| Pubmed ID | 26138103 |
| Abstract | The global spread of dengue virus (DENV) infections has increased viral genetic diversity, some of which appears associated with greater epidemic potential. The mechanisms governing viral fitness in epidemiological settings, however, remain poorly defined. We identified a determinant of fitness in a foreign dominant (PR-2B) DENV serotype 2 (DENV-2) clade, which emerged during the 1994 epidemic in Puerto Rico and replaced an endemic (PR-1) DENV-2 clade. The PR-2B DENV-2 produced increased levels of subgenomicflavivirus RNA (sfRNA) relative to genomic RNA during replication. PR-2B sfRNA showed sequence-dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (RIG-I)-induced type I interferon expression. Our findings demonstrate a distinctive viral RNA-host protein interaction to evade the innate immune response for increased epidemiological fitness. |
| Used Model | HuH-7 |
| DOI | 10.1126/science.aab3369 |
