| Gene Name | SCARB2 |
| HF Protein Name | Lysosome membrane protein 2 |
| HF Function | Required for virus entry |
| Uniprot ID | Q14108 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 950 |
| Host Factor (HF) Name in Paper | SCARB2 |
| Gene synonyms | CD36L2 LIMP2 LIMPII |
| Ensemble Gene ID | ENSG00000138760 |
| Ensemble Transcript | ENST00000264896 [Q14108-1];ENST00000452464 [Q14108-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000139, GO:0001508, GO:0001618, GO:0002532, GO:0005044, GO:0005765, GO:0005789, GO:0005886, GO:0005925, GO:0006622, GO:0006631, GO:0006911, GO:0009986, GO:0010008, GO:0010976, GO:0016020, GO:0016021, GO:0019899, GO:0030665, GO:0031664, GO:0031902, GO:0043202, GO:0061024, GO:0070062, GO:0099600, GO:1904978, GO:1905123, GO:1905671, |
| MINT ID | Q14108 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 254900 |
| PANTHER ID | PTHR11923 |
| PDB ID(s) | 4F7B, 4Q4B, 4Q4F, 4TVZ, 4TW0, 4TW2, 5UPH, |
| pfam ID | PF01130, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Enterovirus 71 |
| Virus Short Name | EV-71 |
| Order | Picornavirales |
| Virus Family | Picornaviridae |
| Virus Subfamily | N.A. |
| Genus | Enterovirus |
| Species | Enterovirus A |
| Host | Human, mammals |
| Cell Tropism | The gastrointestinal trac |
| Associated Disease | Hand, foot and mouth disease, meningitis |
| Mode of Transmission | Either fecal-oral or respiratory |
| VIPR DB link | https://www.viprbrc.org/brc/home.spg?decorator=picorna |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/234/picornaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Picornaviridae |
| Paper Title | Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71 |
| Author's Name | Minghao Dang, Xiangxi Wang, Quan Wang, Yaxin Wang, Jianping Lin, Yuna Sun, Xuemei Li, Liguo Zhang, Zhiyong Lou, Junzhi Wang, Zihe Rao |
| Journal Name | Protein&Cell |
| Pubmed ID | 24986489 |
| Abstract | Unlike the well-established picture for the entry of enveloped viruses, the mechanism of cellular entry of non-enveloped eukaryotic viruses remains largely mysterious. Picornaviruses are representative models for such viruses, and initiate this entry process by their functional receptors. Here we present the structural and functional studies of SCARB2, a functional receptor of the important human enterovirus 71 (EV71). SCARB2 is responsible for attachment as well as uncoating of EV71. Differences in the structures of SCARB2 under neutral and acidic conditions reveal that SCARB2 undergoes a pivotal pH-dependent conformational change which opens a lipid-transfer tunnel to mediate the expulsion of a hydrophobic pocket factor from the virion, a pre-requisite for uncoating. We have also identified the key residues essential for attachment to SCARB2, identifying the canyon region of EV71 as mediating the receptor interaction. Together these results provide a clear understanding of cellular attachment and initiation of uncoating for enteroviruses. |
| Used Model | 293T cells and Sf9 cells |
| DOI | 10.1007/s13238-014-0087-3 |
