| Gene Name | ATP1B3 |
| HF Protein Name | Sodium/potassium-transporting ATPase subunit beta-3 |
| HF Function | Antiviral host factor, induces the production of type-I interferons |
| Uniprot ID | P54709 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 483 |
| Host Factor (HF) Name in Paper | ATP1B3 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000069849 |
| Ensemble Transcript | ENST00000286371 [P54709-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001671, GO:0005391, GO:0005886, GO:0005890, GO:0005901, GO:0006883, GO:0010107, GO:0030007, GO:0032781, GO:0034220, GO:0036376, GO:0042470, GO:0050821, GO:0050900, GO:0051117, GO:0070062, GO:0072659, GO:0086009, GO:1901018, GO:1903278, GO:1903288, GO:1903779, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 601867 |
| PANTHER ID | PTHR11523 |
| PDB ID(s) | N.A., |
| pfam ID | PF00287, |
| Drug Bank ID | DB09479, |
| ChEMBL ID | CHEMBL2095186 |
| Organism | Homo sapiens (Human) |
| Virus Name | Enterovirus 71 |
| Virus Short Name | EV-71 |
| Order | Picornavirales |
| Virus Family | Picornaviridae |
| Virus Subfamily | N.A. |
| Genus | Enterovirus |
| Species | Enterovirus A |
| Host | Human, mammals |
| Cell Tropism | The gastrointestinal trac |
| Associated Disease | Hand, foot and mouth disease, meningitis |
| Mode of Transmission | Either fecal-oral or respiratory |
| VIPR DB link | https://www.viprbrc.org/brc/home.spg?decorator=picorna |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/234/picornaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Picornaviridae |
| Paper Title | ATP1B3: a virus-induced host factor against EV71 replication by up-regulating the production of type-I interferons |
| Author's Name | Yanfang Lu, Hongyan Hou, Feng Wang, Long Qiao, Xiong Wang, Jing Yu , Weiyong Liu, Ziyong Sun |
| Journal Name | Virology |
| Pubmed ID | 27240146 |
| Abstract | Enterovirus 71 (EV71) infection can cause severe diseases, and is becoming increasingly common in children. In the current study, we carried out yeast two-hybrid assays to screen human proteins that could interact with 3A protein of EV71. Human beta3 subunit of Na(+)/K(+)-ATPase (ATP1B3) protein was demonstrated to interact with the 3A protein of EV71. Although 3A protein had no effect on the expression of ATP1B3, EV71 infection resulted in elevated expression of ATP1B3 in RD cell line, both on messenger RNA (mRNA) and protein levels. Interestingly, knockdown of ATP1B3 could significantly increase the replication of EV71, whereas overexpression of ATP1B3 significantly suppressed the replication of EV71 in RD cells. Furthermore, we demonstrated that the expression of ATP1B3could induce the production of type-I interferons. Our study demonstrated that ATP1B3 inhibit EV71 replication by enhancing the production of type-I interferons, which could act as a potential therapeutic target in EV71 infection. |
| Used Model | HEK 293T and RD cells |
| DOI | 10.1016/j.virol.2016.05.013 |
