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Virus Details


VHFID2867

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name ITGB3
HF Protein Name Integrin beta-3
HF Function Integrin alpha v beta 6 is a receptor for coxsackievirus A9
Uniprot ID P05106
Protein Sequence View Fasta Sequence
NCBI Gene ID 3690
Host Factor (HF) Name in Paper ITGB3
Gene synonyms GP3A
Ensemble Gene ID ENSG00000259207
Ensemble Transcript ENST00000559488 [P05106-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001618, GO:0001934, GO:0001938, GO:0001968, GO:0002020, GO:0002576, GO:0003756, GO:0005161, GO:0005178, GO:0005634, GO:0005886, GO:0005887, GO:0005925, GO:0007044, GO:0007155, GO:0007160, GO:0007229, GO:0007596, GO:0008305, GO:0009986, GO:0010595, GO:0010745, GO:0010888, GO:0014909, GO:0015026, GO:0019899, GO:0030168, GO:0030198, GO:0030949, GO:0031092, GO:0031258, GO:0031527, GO:0031528, GO:0031589, GO:0032147, GO:0032369, GO:0032587, GO:0033627, GO:0034113, GO:0034446, GO:0034683, GO:0035295, GO:0035866, GO:0035867, GO:0035868, GO:0038027, GO:0042060, GO:0042470, GO:0042802, GO:0043184, GO:0043235, GO:0043277, GO:0045124, GO:0045715, GO:0046718, GO:0048010, GO:0048333, GO:0050731, GO:0050748, GO:0050839, GO:0050840, GO:0050900, GO:0050919, GO:0060055, GO:0070062, GO:0070527, GO:0071062,
MINT ID P05106
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 173470
PANTHER ID PTHR10082;PTHR10082:SF25
PDB ID(s) 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1RN0, 1S4X, 1TYE, 1U8C, 2INI, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2N9Y, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4Z7N, 4Z7O, 4Z7Q, 5HDB, 6AVQ, 6AVR, 6AVU,
pfam ID PF07974, PF08725, PF07965, PF00362, PF17205,
Drug Bank ID DB00054, DB00098, DB00063, DB04863, DB05787, DB00775,
ChEMBL ID CHEMBL2111461
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Coxsackie B virus
Virus Short Name CV-B
Order Picornavirales
Virus Family Picornaviridae
Virus Subfamily N.A.
Genus Enterovirus
Species Enterovirus B
Host Human, mammals
Cell Tropism The gastrointestinal trac
Associated Disease Coxsackievirus-induced cardiomyopathy
Mode of Transmission Either fecal-oral or respiratory
VIPR DB link https://www.viprbrc.org/brc/home.spg?decorator=picorna
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/234/picornaviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Picornaviridae

Publication Information

Paper Title Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9
Author's Name Cigdem H. Williams, Tommi Kajander, Timo Hyypia, Terry Jackson, Dean Sheppard, and Glyn Stanway
Journal Name Journal Of Virology
Pubmed ID 15194773
Abstract Coxsackievirus A9 (CAV9), a member of the Enterovirus genus of Picornaviridae, is a common human pathogen and is one of a significant number of viruses containing a functional arginine-glycine-aspartic acid (RGD) motif in one of their capsid proteins. Previous studies identified the RGD-recognizing integrin alpha(v)beta(3) as its cellular receptor. However, integrin alpha(v)beta(6) has been shown to be an efficient receptor for another RGD-containing picornavirus, foot-and-mouth disease virus (FMDV). In view of the similarity in sequence context of the RGD motifs in CAV9 and FMDV, we investigated whether alpha(v)beta(6) can also serve as a receptor for CAV9. We found that CAV9 can bind to purified alpha(v)beta(6) and also to SW480 cells transfected with beta(6) cDNA, allowing expression of alpha(v)beta(6) on their surface, but it cannot bind to mock-transfected cells. In addition, a higher yield of CAV9 was obtained in beta(6)-expressing cells than in mock-transfected cells. There was no similar enhancement in infection with an RGD-less CAV9 mutant. We also found beta(6) on the surface of GMK cells, a cell line which CAV9 infects efficiently by an RGD-dependent mechanism. Significantly, this infection is blocked by an antibody to alpha(v)beta(6), while this antibody did not block the low level of infection by the RGD-less mutant. Thus, integrin alpha(v)beta(6) is an RGD-dependent receptor for CAV9 and may be important in natural CAV9 infections.
Used Model RD cells
DOI 10.1128/JVI.78.13.6967-6973.2004