| Gene Name | OCLN |
| HF Protein Name | Occludin |
| HF Function | Required for Coxsackievirus Entry |
| Uniprot ID | Q16625 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 100506658 |
| Host Factor (HF) Name in Paper | OCLN |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000197822 |
| Ensemble Transcript | ENST00000355237 [Q16625-1];ENST00000396442 [Q16625-1];ENST00000538151 [Q16625-4] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005886, GO:0005911, GO:0005923, GO:0016021, GO:0016324, GO:0016327, GO:0016328, GO:0019904, GO:0030054, GO:0030139, GO:0031410, GO:0045216, GO:0065003, GO:0070673, GO:0070830, GO:0071356, GO:2000810, |
| MINT ID | Q16625 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 251290 |
| PANTHER ID | PTHR23288;PTHR23288:SF4 |
| PDB ID(s) | 1WPA, 1XAW, 3G7C, |
| pfam ID | PF01284, PF07303, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Coxsackie B virus |
| Virus Short Name | CV-B |
| Order | Picornavirales |
| Virus Family | Picornaviridae |
| Virus Subfamily | N.A. |
| Genus | Enterovirus |
| Species | Enterovirus B |
| Host | Human, mammals |
| Cell Tropism | The gastrointestinal trac |
| Associated Disease | Coxsackievirus-induced cardiomyopathy |
| Mode of Transmission | Either fecal-oral or respiratory |
| VIPR DB link | https://www.viprbrc.org/brc/home.spg?decorator=picorna |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/234/picornaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Picornaviridae |
| Paper Title | Coxsackievirus Entry across Epithelial Tight Junctions Requires Occludin and the Small GTPases Rab34 and Rab5 |
| Author's Name | Carolyn B. Coyne, Le Shen, Jerrold R. Turner, and Jeffrey M. Bergelson |
| Journal Name | Cell Host & Microbe |
| Pubmed ID | 18005733 |
| Abstract | The major group B coxsackievirus (CVB) receptor is a component of the epithelial tight junction (TJ), a protein complex that regulates the selective passage of ions and molecules across the epithelium. CVB enters polarized epithelial cells from the TJ, causing a transient disruption of TJ integrity. Here we show that CVB does not induce major reorganization of the TJ, but stimulates the specific internalization of occludin-a TJ integral membrane component-within macropinosomes. Although occludin does not interact directly with virus, depletion of occludin prevents CVB entry into the cytoplasm and inhibits infection. Both occludin internalization and CVB entryrequire caveolin but not dynamin both are blocked by inhibitors of macropinocytosis and require the activity of Rab34, Ras, and Rab5, GTPases known to regulate macropinocytosis. Thus, CVB entry depends on occludin and occurs by a process that combines aspects of caveolar endocytosis with features characteristic of macropinocytosis. |
| Used Model | CHO and Caco-2 cells |
| DOI | 10.1016/j.chom.2007.07.003 |
