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Virus Details


VHFID2894

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name CTSB
HF Protein Name Cathepsin B
HF Function Required for CVB virus infection
Uniprot ID P07858
Protein Sequence View Fasta Sequence
NCBI Gene ID 1508
Host Factor (HF) Name in Paper CTSB
Gene synonyms CPSB
Ensemble Gene ID ENSG00000164733
Ensemble Transcript ENST00000345125;ENST00000353047;ENST00000453527;ENST00000530640;ENST00000531089;ENST00000533455;ENST00000534510
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0002224, GO:0004197, GO:0004252, GO:0005518, GO:0005576, GO:0005615, GO:0005622, GO:0005730, GO:0005739, GO:0005764, GO:0006508, GO:0008233, GO:0008234, GO:0030574, GO:0030855, GO:0036021, GO:0042470, GO:0042981, GO:0043231, GO:0043312, GO:0043394, GO:0046697, GO:0046718, GO:0048471, GO:0050790, GO:0051603, GO:0070062, GO:0097067, GO:1904813,
MINT ID P07858
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 116810
PANTHER ID PTHR12411
PDB ID(s) 1CSB, 1GMY, 1HUC, 1PBH, 2IPP, 2PBH, 3AI8, 3CBJ, 3CBK, 3K9M, 3PBH, 5MBL, 5MBM, 6AY2,
pfam ID PF00112, PF08127,
Drug Bank ID DB02108, DB03329, DB02148, DB02685, DB03588, DB02855, DB04126,
ChEMBL ID CHEMBL4072
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Coxsackie B virus
Virus Short Name CV-B
Order Picornavirales
Virus Family Picornaviridae
Virus Subfamily N.A.
Genus Enterovirus
Species Enterovirus B
Host Human, mammals
Cell Tropism The gastrointestinal trac
Associated Disease Coxsackievirus-induced cardiomyopathy
Mode of Transmission Either fecal-oral or respiratory
VIPR DB link https://www.viprbrc.org/brc/home.spg?decorator=picorna
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/234/picornaviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Picornaviridae

Publication Information

Paper Title Comparative RNAi screening reveals host factors involved in enterovirus infection of polarizedendothelial monolayers
Author's Name Carolyn B. Coyne, Rebecca Bozym, Stefanie A. Morosky, Sheri L. Hanna, Amitava Mukherjee, Matthew Tudor, Kwang Sik Kim, and Sara Cherry
Journal Name Cell Host & Microbe
Pubmed ID 21238948
Abstract Enteroviruses, including coxsackievirus B (CVB) and poliovirus (PV), can access the CNS through the blood brain barrier (BBB) endothelium to cause aseptic meningitis. To identify cellular components required for CVB and PV infection of human brain microvascular endothelial cells, an in vitro BBB model, we performed comparative RNAi screens and identified 117 genes that influenced infection. Whereas a large proportion of genes whose depletion enhanced infection (17 of 22) were broadly antienteroviral, only 46 of the 95 genes whose depletion inhibited infection were required by both CVB and PV and included components of cell signaling pathways such as adenylate cyclases. Downregulation of genes including Rab GTPases, Src tyrosine kinases, and tyrosine phosphatases displayed specificity in their requirement for either CVB or PV infection. These findings highlight the pathways hijacked by enteroviruses for entry and replication in the BBB endothelium, a specialized and clinically relevant cell type for these viruses.
Used Model HBMEC and Caco-2 cells
DOI 10.1016/j.chom.2011.01.001