Hostfactor - VHFIDB

Gene Name	ICAM1
HF Protein Name	Intercellular adhesion molecule 1
HF Function	Cellular receptor for coxsackievirus A21
Uniprot ID	P05362
Protein Sequence	View Fasta Sequence
NCBI Gene ID	3383
Host Factor (HF) Name in Paper	ICAM1
Gene synonyms	N.A.
Ensemble Gene ID	ENSG00000090339
Ensemble Transcript	ENST00000264832
KEGG ID	Go to KEGG Database
Gene Ontology ID(s)	GO:0001541, GO:0001618, GO:0001772, GO:0001910, GO:0001975, GO:0002291, GO:0002438, GO:0002457, GO:0002693, GO:0004872, GO:0004888, GO:0005178, GO:0005615, GO:0005886, GO:0005887, GO:0005925, GO:0007155, GO:0007157, GO:0007159, GO:0007569, GO:0007605, GO:0008360, GO:0009897, GO:0009986, GO:0010212, GO:0010477, GO:0016020, GO:0019221, GO:0022614, GO:0030198, GO:0030838, GO:0031012, GO:0031669, GO:0032868, GO:0033627, GO:0034698, GO:0043200, GO:0043547, GO:0044406, GO:0045121, GO:0045429, GO:0045471, GO:0045907, GO:0046688, GO:0046813, GO:0050731, GO:0050776, GO:0050900, GO:0051092, GO:0051926, GO:0060333, GO:0061028, GO:0070062, GO:0070374, GO:0071222, GO:0071312, GO:0071333, GO:0071347, GO:0071354, GO:0071356, GO:0071456, GO:0071549, GO:0090557, GO:0097368, GO:1900027, GO:1902042, GO:1904996, GO:1990830, GO:2000352,
MINT ID	P05362
STRING	Click to see interaction map
GWAS Analysis	Click to see gwas analysis
OMIM ID	147840
PANTHER ID	N.A.
PDB ID(s)	1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1IJ4, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX, 5MZA, 6EIT,
pfam ID	PF03921,
Drug Bank ID	DB08818, DB00108,
ChEMBL ID	CHEMBL3070
Organism	Homo sapiens (Human)

Virus Name	coxsackievirus A21
Virus Short Name	CV-A21
Order	Picornavirales
Virus Family	Picornaviridae
Virus Subfamily	N.A.
Genus	Enterovirus
Species	Enterovirus C
Host	Human, mammals
Cell Tropism	Upper respiratory tract
Associated Disease	Respiratory disease
Mode of Transmission	Feces,saliva, nasal mucus, or sputum
VIPR DB link	https://www.viprbrc.org/brc/home.spg?decorator=picorna
ICTV DB link	https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/234/picornaviridae
Virus Host DB link	http://www.genome.jp/virushostdb/view/?virus_lineage=Picornaviridae

Paper Title	Interaction of coxsackievirus A21 with its cellular receptor, ICAM-1
Author's Name	Xiao C, Bator CM, Bowman VD, Rieder E, He Y, Hebert B, Bella J, Baker TS, Wimmer E, Kuhn RJ, Rossmann MG.
Journal Name	Journal Of Virology
Pubmed ID	11160747
Abstract	CoxsackievirusÂ A21Â (CAV21), like human rhinoviruses (HRVs), is a causative agent of the common cold. It uses the sameÂ cellularreceptor,Â intercellular adhesion molecule 1Â (ICAM-1), as does the major group of HRVs unlike HRVs, however, it is stable at acid pH. The cryoelectron microscopy (cryoEM) image reconstruction of CAV21 is consistent with the highly homologous crystal structure of poliovirus 1 like other enteroviruses and HRVs, CAV21 has a canyon-like depression around each of the 12 fivefold vertices. A cryoEM reconstruction of CAV21 complexed withÂ ICAM-1Â shows all five domains of the extracellular component ofÂ ICAM-1. The known atomic structure of theÂ ICAM-1Â amino-terminal domains D1 and D2 has been fitted into the cryoEM density of the complex. The site ofÂ ICAM-1binding within the canyon of CAV21 overlaps the site ofÂ receptorÂ recognition utilized by rhinoviruses and polioviruses. Interactions within this common region may be essential for triggering viral destabilization after attachment to susceptibleÂ cells.
Used Model	HeLa cells
DOI	10.1128/JVI.75.5.2444-2451.2001

Virus Details