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Virus Details


VHFID3193

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name ITGB3
HF Protein Name Integrin beta-3
HF Function Essential for virus entry
Uniprot ID P05106
Protein Sequence View Fasta Sequence
NCBI Gene ID 3690
Host Factor (HF) Name in Paper ITGB3
Gene synonyms GP3A
Ensemble Gene ID ENSG00000259207
Ensemble Transcript ENST00000559488 [P05106-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001618, GO:0001934, GO:0001938, GO:0001968, GO:0002020, GO:0002576, GO:0003756, GO:0005161, GO:0005178, GO:0005634, GO:0005886, GO:0005887, GO:0005925, GO:0007044, GO:0007155, GO:0007160, GO:0007229, GO:0007596, GO:0008305, GO:0009986, GO:0010595, GO:0010745, GO:0010888, GO:0014909, GO:0015026, GO:0019899, GO:0030168, GO:0030198, GO:0030949, GO:0031092, GO:0031258, GO:0031527, GO:0031528, GO:0031589, GO:0032147, GO:0032369, GO:0032587, GO:0033627, GO:0034113, GO:0034446, GO:0034683, GO:0035295, GO:0035866, GO:0035867, GO:0035868, GO:0038027, GO:0042060, GO:0042470, GO:0042802, GO:0043184, GO:0043235, GO:0043277, GO:0045124, GO:0045715, GO:0046718, GO:0048010, GO:0048333, GO:0050731, GO:0050748, GO:0050839, GO:0050840, GO:0050900, GO:0050919, GO:0060055, GO:0070062, GO:0070527, GO:0071062,
MINT ID P05106
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 173470
PANTHER ID PTHR10082;PTHR10082:SF25
PDB ID(s) 1JV2, 1KUP, 1KUZ, 1L5G, 1M1X, 1M8O, 1MIZ, 1MK7, 1MK9, 1RN0, 1S4X, 1TYE, 1U8C, 2INI, 2K9J, 2KNC, 2KV9, 2L1C, 2L91, 2LJD, 2LJE, 2LJF, 2MTP, 2N9Y, 2Q6W, 2RMZ, 2RN0, 2VC2, 2VDK, 2VDL, 2VDM, 2VDN, 2VDO, 2VDP, 2VDQ, 2VDR, 3FCS, 3FCU, 3IJE, 3NID, 3NIF, 3NIG, 3T3M, 3T3P, 3ZDX, 3ZDY, 3ZDZ, 3ZE0, 3ZE1, 3ZE2, 4CAK, 4G1E, 4G1M, 4MMX, 4MMY, 4MMZ, 4O02, 4Z7N, 4Z7O, 4Z7Q, 5HDB, 6AVQ, 6AVR, 6AVU,
pfam ID PF07974, PF08725, PF07965, PF00362, PF17205,
Drug Bank ID DB00054, DB00098, DB00063, DB04863, DB05787, DB00775,
ChEMBL ID CHEMBL2111461
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Hantaan virus
Virus Short Name HTNV
Order Bunyavirales
Virus Family Hantaviridae
Virus Subfamily N.A.
Genus Orthohantavirus
Species Hantaan virus
Host Rodents and human
Cell Tropism N.A.
Associated Disease Hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome
Mode of Transmission By urine and saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=bunya
ICTV DB link N.A.
Virus Host DB link N.A.

Publication Information

Paper Title Cellular entry of Hantaan virus A9 strain: Specific interactions with b3 integrins and a novel 70 kDa protein
Author's Name Dan Lei Mou, Ying Peng Wang, Chang Xing Huang, Guang Yu Li, Lei Pan, Wei Song Yang, Xue Fan Bai
Journal Name Biochemical and Biophysical Research Communications
Pubmed ID 16310165
Abstract Cellular entry of pathogenic hantaviruses had been shown to be mediated by beta3 integrins. However, no direct evidence exists that hantavirus binds to beta3 integrins, and integrin beta3 subunit is not expressed on some cells permissive to hantavirus infection. In this report, utilizing beta3-integrin-transfected CHO cells, we demonstrated that integrin beta3 subunit renders CHO cells susceptible to Chinese Hantaan virus (HTN) strain A9 (isolated in China), and the viral infection was correspondingly inhibited by antibodies to alphavbeta3, alphaIIbbeta3, beta3, and alphav integrins. Furthermore, virus overlay protein-binding assay and quarternary Western analysis indicate that HTN A9 directly interacts with beta3 integrins and an unidentified 70kDa protein. These findings indicate that beta3 integrins play a crucial role in cellular entry of HTN A9 via specific interactions with the virus. In addition, a novel 70kDa protein may serves as a candidate receptor or alternative cellular component for interaction with HTN.
Used Model CHO cells
DOI 10.1016/j.bbrc.2005.11.049