| Gene Name | IFITM3 |
| HF Protein Name | Interferon-induced transmembrane protein 3 |
| HF Function | Inhibits virus infection |
| Uniprot ID | Q01628 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 10410 |
| Host Factor (HF) Name in Paper | IFITM3 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000142089 |
| Ensemble Transcript | ENST00000399808 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005765, GO:0005886, GO:0006955, GO:0009615, GO:0016021, GO:0031902, GO:0032897, GO:0034341, GO:0035455, GO:0035456, GO:0045071, GO:0046597, GO:0051607, GO:0060337, GO:0070062, |
| MINT ID | Q01628 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605579 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF04505, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Hantaan virus |
| Virus Short Name | HTNV |
| Order | Bunyavirales |
| Virus Family | Hantaviridae |
| Virus Subfamily | N.A. |
| Genus | Orthohantavirus |
| Species | Hantaan virus |
| Host | Rodents and human |
| Cell Tropism | N.A. |
| Associated Disease | Hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome |
| Mode of Transmission | By urine and saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=bunya |
| ICTV DB link | N.A. |
| Virus Host DB link | N.A. |
| Paper Title | interferon-induced Transmembrane Protein 3 inhibits hantaan Virus infection, and its single nucleotide Polymorphism rs12252 in uences the severity of hemorrhagic Fever with renal syndrome |
| Author's Name | Zheng Xu-yang, Bian Pei-yu, Ye Chuan-tao, Ye Wei, Ma Hong-wei, Tang Kang, Zhang Chun-mei, Lei Ying-feng, Wei Xin, Wang Ping-zhong, Huang Chang-xing, Bai Xue-fan, Zhang Ying and Jia Zhan-sheng |
| Journal Name | Frontiers In Microbiology |
| Pubmed ID | 28096800 |
| Abstract | Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polymorphisms (SNP) rs12252 C allele and CC genotype associated with the disease severity and HTNV load in the plasma of HFRS patients. In vitro experiments showed that the truncated protein produced by the rs12252 C allele exhibited an impaired anti-HTNV activity. We also proved that IFITM3 was able to inhibit HTNV infection in both HUVEC and A549 cells by overexpression and RNAi assays, likely via a mechanism of inhibiting virus entry demonstrated by binding and entry assay. Localization of IFITM3 in late endosomes was also observed. In addition, we demonstrated that the transcription of IFITM3 is negatively regulated by an lncRNA negative regulator of interferon response (NRIR). Taken together, we conclude that IFITM3, negatively regulated by NRIR, inhibits HTNV infection, and its SNP rs12252 correlates with the plasma HTNV load and the disease severity of patients with HFRS. |
| Used Model | HUVEC cells |
| DOI | 10.3389/fimmu.2016.00535 |
