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Virus Details


VHFID3195

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name TLR4
HF Protein Name Toll-like receptor 4
HF Function Activates innate immune system
Uniprot ID O00206
Protein Sequence View Fasta Sequence
NCBI Gene ID 7099
Host Factor (HF) Name in Paper TLR4
Gene synonyms N.A.
Ensemble Gene ID ENSG00000136869
Ensemble Transcript ENST00000355622 [O00206-1];ENST00000394487 [O00206-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000187, GO:0001530, GO:0001875, GO:0002224, GO:0002755, GO:0002756, GO:0004872, GO:0004888, GO:0005102, GO:0005622, GO:0005737, GO:0005769, GO:0005886, GO:0005887, GO:0006954, GO:0006955, GO:0007249, GO:0007252, GO:0009897, GO:0009986, GO:0010008, GO:0010572, GO:0010628, GO:0016046, GO:0031226, GO:0031663, GO:0032496, GO:0032497, GO:0032689, GO:0032700, GO:0032707, GO:0032715, GO:0032720, GO:0032722, GO:0032727, GO:0032728, GO:0032729, GO:0032732, GO:0032733, GO:0032735, GO:0032755, GO:0032757, GO:0032760, GO:0034128, GO:0034142, GO:0035666, GO:0042088, GO:0042116, GO:0042346, GO:0042535, GO:0042742, GO:0043032, GO:0043235, GO:0045084, GO:0045087, GO:0045416, GO:0045429, GO:0045671, GO:0045944, GO:0046696, GO:0046982, GO:0048471, GO:0050702, GO:0050718, GO:0050729, GO:0050829, GO:0051092, GO:0051770, GO:0060729, GO:0070266, GO:0070373, GO:0071222, GO:0071260, GO:0097190, GO:0140052, GO:1900017, GO:1900227, GO:1903223, GO:1903428, GO:1904646,
MINT ID O00206
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 603030
PANTHER ID PTHR44568
PDB ID(s) 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA, 4G8A, 5NAM,
pfam ID PF13516, PF13855, PF01582,
Drug Bank ID DB02767, DB04933, DB03017, DB08231, DB01183, DB05475,
ChEMBL ID CHEMBL5255
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Hantaan virus
Virus Short Name HTNV
Order Bunyavirales
Virus Family Hantaviridae
Virus Subfamily N.A.
Genus Orthohantavirus
Species Hantaan virus
Host Rodents and human
Cell Tropism N.A.
Associated Disease Hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome
Mode of Transmission By urine and saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=bunya
ICTV DB link N.A.
Virus Host DB link N.A.

Publication Information

Paper Title Hantaan Virus Triggers TLR4-Dependent Innate Immune Responses
Author's Name Hai-Tao Yu , Hong Jiang, Ye Zhang, Xue-Ping Nan, Yu Li, Wei Wang, Wei Jiang, Dong-Qiang Yang, Wen-Jing Su, Jiu-Ping Wang, Ping-Zhong Wang , and Xue-Fan Bai
Journal Name Viral Immunology
Pubmed ID 22775464
Abstract The innate immune response induced by Hantavirus is responsible for endothelial cell dysfunction and viral pathogenicity. Recent studies demonstrate that TLR4 expression is upregulated and mediates the secretion of several cytokines in Hantaan virus (HTNV)-infected endothelial cells. To examine viral interactions with host endothelial cells and characterize the innate antiviral responses associated with Toll-like receptors, we selected TLR4 as the target molecule to investigate anti-hantavirus immunity. TLR4 mRNA-silenced EVC-304 (EVC-304 TLR4–) cells and EVC-304 cells were used to investigate signaling molecules downstream of TLR4. The expression of the adaptor protein TRIF was higher in HTNV-infected EVC-304 cells than in EVC-304 TLR4– cells. However, there was no apparent difference in the expression of MyD88 in either cell line. The transcription factors for NF-κB and IRF-3 were translocated from the cytoplasm into the nucleus in HTNV-infected EVC-304 cells, but not in HTNV-infected EVC-304 TLR4– cells. Our results demonstrate that TLR4 may play an important role in the antiviral immunity of the host against HTNV infection through an MyD88-independent signaling pathway.
Used Model Vero E6 cells
DOI 10.1089/vim.2012.0005