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Virus Details


VHFID3211

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name SAMHD1
HF Protein Name Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
HF Function SAMHD1 inhibits HBV replication at the reverse transcription step
Uniprot ID Q9Y3Z3
Protein Sequence View Fasta Sequence
NCBI Gene ID 25939
Host Factor (HF) Name in Paper SAMHD1
Gene synonyms MOP5
Ensemble Gene ID ENSG00000101347
Ensemble Transcript ENST00000262878 [Q9Y3Z3-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0003676, GO:0003723, GO:0004540, GO:0005622, GO:0005634, GO:0005654, GO:0005886, GO:0006203, GO:0006955, GO:0008270, GO:0008832, GO:0009264, GO:0016793, GO:0032567, GO:0042802, GO:0045088, GO:0046061, GO:0051289, GO:0051607, GO:0060337,
MINT ID N.A.
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 606754
PANTHER ID N.A.
PDB ID(s) 2E8O, 3U1N, 4BZB, 4BZC, 4CC9, 4MZ7, 4Q7H, 4QFX, 4QFY, 4QFZ, 4QG0, 4QG1, 4QG2, 4QG4, 4RXO, 4RXP, 4RXQ, 4RXR, 4RXS, 4TNP, 4TNQ, 4TNR, 4TNX, 4TNY, 4TNZ, 4TO0, 4TO1, 4TO2, 4TO3, 4TO4, 4TO5, 4TO6, 4ZWE, 4ZWG, 5AO0, 5AO1, 5AO2, 5AO3, 5AO4,
pfam ID PF01966, PF07647,
Drug Bank ID N.A.,
ChEMBL ID N.A.
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Hepatitis B virus
Virus Short Name HBV
Order Unassigned
Virus Family Hepadnaviridae
Virus Subfamily N.A.
Genus Orthohepadnavirus
Species Hepatitis B virus
Host Human, mammals
Cell Tropism Hepatocytes
Associated Disease Hepatitis, hepatocellular carcinoma(chronic infections), cirrhosis
Mode of Transmission Sexual contact, blood, maternal-neonatal
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae
Virus Host DB link N.A.

Publication Information

Paper Title Inhibition of hepatitis B virus replication by a dNTPase-dependent function of the host restriction factor SAMHD1
Author's Name Gi Uk Jeong, Il-Hyun Park, Kwangseog Ahn, Byung-Yoon Ahn
Journal Name Virology
Pubmed ID 27179347
Abstract SAMHD1 is a cellular protein that possesses dNTPase activity and inhibits retroviruses and DNA viruses through the depletion of cellular dNTPs. However, recent evidence suggests the existence of alternative or additional mechanisms that involve novel nuclease activities. Hepatitis B virus is a DNA virus but resembles retroviruses in that its DNA genome is synthesized via reverse transcription of an RNA transcript. SAMHD1 was shown to inhibit the expression and replication of a transfected HBV DNA. We further investigated the antiviral mechanisms in a newly developed infection assay. Our data indicated that SAMHD1 exerts a profound antiviral effect. In addition, unlike previous findings, our results demonstrate the essential role of SAMHD1 dNTPase. SAMHD1 did not affect virion-derived cccDNA and gene expression but specifically inhibited viral DNA synthesis. These results indicate that SAMHD1 inhibits HBV replication at the reverse transcription step, most likely through the depletion of cellular dNTPs.
Used Model Huh7, HepG2 and HEK 293 cells
DOI 10.1016/j.virol.2016.05.001