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Virus Details


VHFID3223

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name TLR4
HF Protein Name Toll-like receptor 4
HF Function Antiviral protein
Uniprot ID O00206
Protein Sequence View Fasta Sequence
NCBI Gene ID 7099
Host Factor (HF) Name in Paper TLR4
Gene synonyms N.A.
Ensemble Gene ID ENSG00000136869
Ensemble Transcript ENST00000355622 [O00206-1];ENST00000394487 [O00206-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000187, GO:0001530, GO:0001875, GO:0002224, GO:0002755, GO:0002756, GO:0004872, GO:0004888, GO:0005102, GO:0005622, GO:0005737, GO:0005769, GO:0005886, GO:0005887, GO:0006954, GO:0006955, GO:0007249, GO:0007252, GO:0009897, GO:0009986, GO:0010008, GO:0010572, GO:0010628, GO:0016046, GO:0031226, GO:0031663, GO:0032496, GO:0032497, GO:0032689, GO:0032700, GO:0032707, GO:0032715, GO:0032720, GO:0032722, GO:0032727, GO:0032728, GO:0032729, GO:0032732, GO:0032733, GO:0032735, GO:0032755, GO:0032757, GO:0032760, GO:0034128, GO:0034142, GO:0035666, GO:0042088, GO:0042116, GO:0042346, GO:0042535, GO:0042742, GO:0043032, GO:0043235, GO:0045084, GO:0045087, GO:0045416, GO:0045429, GO:0045671, GO:0045944, GO:0046696, GO:0046982, GO:0048471, GO:0050702, GO:0050718, GO:0050729, GO:0050829, GO:0051092, GO:0051770, GO:0060729, GO:0070266, GO:0070373, GO:0071222, GO:0071260, GO:0097190, GO:0140052, GO:1900017, GO:1900227, GO:1903223, GO:1903428, GO:1904646,
MINT ID O00206
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 603030
PANTHER ID PTHR44568
PDB ID(s) 2Z62, 2Z63, 2Z65, 2Z66, 3FXI, 3UL7, 3UL8, 3UL9, 3ULA, 4G8A, 5NAM,
pfam ID PF13516, PF13855, PF01582,
Drug Bank ID DB02767, DB04933, DB03017, DB08231, DB01183, DB05475,
ChEMBL ID CHEMBL5255
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Hepatitis B virus
Virus Short Name HBV
Order Unassigned
Virus Family Hepadnaviridae
Virus Subfamily N.A.
Genus Orthohepadnavirus
Species Hepatitis B virus
Host Human, mammals
Cell Tropism Hepatocytes
Associated Disease Hepatitis, hepatocellular carcinoma(chronic infections), cirrhosis
Mode of Transmission Sexual contact, blood, maternal-neonatal
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/reverse-transcribing-dna-and-rna-viruses-2011/w/rt_viruses/155/hepadnaviridae
Virus Host DB link N.A.

Publication Information

Paper Title Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study
Author's Name Dipanwita Das, Neelakshi Sarkar, Isha Sengupta, Ananya Pal, Debraj Saha, Manikankana Bandopadhyay, Chandrima Das, Jimmy Narayan, Shivram Prasad Singh, Runu Chakravarty
Journal Name World Journal Of Gastroentology
Pubmed ID 28058014
Abstract AIM:Toll like receptors plays a significant anti-viral role in different infections. The aim of this study was to look into the role of toll like receptor 4 (TLR4) in hepatitis B virus (HBV) infection.METHODS: Real time PCR was used to analyze the transcription of TLR4 signaling molecules, cell cycle regulators and HBV DNA viral load after triggering the HepG2.2.15 cells with TLR4 specific ligand. Nuclear factor (NF)-κB translocation on TLR4 activation was analyzed using microscopic techniques. Protein and cell cycle analysis was done using Western Blot and FACS respectively. RESULTS: The present study shows that TLR4 activation represses HBV infection. As a result of HBV suppression, there are several changes in host factors which include partial release in G1/S cell cycle arrest and changes in host epigenetic marks. Finally, it was observed that anti-viral action of TLR4 takes place through the NF-κB pathway. CONCLUSION: The study shows that TLR4 activation in HBV infection brings about changes in hepatocyte microenvironment and can be used for developing a promising therapeutic target in future.
Used Model HepG2.2.15 cells
DOI 10.3748/wjg.v22.i47.10341