| Gene Name | UBTF |
| HF Protein Name | Nucleolar transcription factor 1 |
| HF Function | UBF can inhibit gene expression from viral DNA prior to its replication |
| Uniprot ID | P17480 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 7343 |
| Host Factor (HF) Name in Paper | UBF |
| Gene synonyms | UBF UBF1 |
| Ensemble Gene ID | ENSG00000108312 |
| Ensemble Transcript | ENST00000302904 [P17480-1];ENST00000343638 [P17480-2];ENST00000393606 [P17480-2];ENST00000436088 [P17480-1];ENST00000526094 [P17480-2];ENST00000529383 [P17480-1];ENST00000533177 [P17480-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000981, GO:0001164, GO:0001165, GO:0001650, GO:0003682, GO:0003723, GO:0005634, GO:0005654, GO:0005730, GO:0006356, GO:0006360, GO:0006361 GO:0006362, GO:0006363, GO:0045943, GO:0097110, |
| MINT ID | P17480 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600673 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1K99, 1L8Y, 1L8Z, 2HDZ, |
| pfam ID | PF00505, PF09011, PF14887, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Upstream binding factor inhibits herpes simplex virus replication |
| Author's Name | Gabriel Ouellet Lavallee, Angela Pearson |
| Journal Name | Virology |
| Pubmed ID | 25965800 |
| Abstract | Herpes simplex virus 1 (HSV-1) infection induces changes to the host cell nucleus including relocalization of the cellular protein Upstream Binding Factor (UBF) from the nucleolus to viral replication compartments (VRCs). Herein, we tested the hypothesis that UBF is recruited to VRCs to promote viral DNA replication. Surprisingly, infection of UBF-depleted HeLa cells with HSV-1 or HSV-2 produced higher viral titers compared to controls. Reduced expression of UBF also led to a progressive increase in the relative amount of HSV-1 DNA versus controls, and increased levels of HSV-1 ICP27 and TK mRNA and protein, regardless of whether viral DNA replication was inhibited or not. Our results suggest that UBF can inhibit gene expression from viral DNA prior to its replication. A similar but smaller effect on viral titers was observed in human foreskin fibroblasts. This is the first report of UBF having a restrictive effect on replication of a virus. |
| Used Model | Hela cells |
| DOI | 10.1016/j.virol.2015.04.003 |
