| Gene Name | ZC3HAV1 |
| HF Protein Name | Zinc finger CCCH-type antiviral protein 1 |
| HF Function | Inhibits HSV-1 replication |
| Uniprot ID | Q7Z2W4 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 56829 |
| Host Factor (HF) Name in Paper | ZAP |
| Gene synonyms | ZC3HDC2 |
| Ensemble Gene ID | ENSG00000105939 |
| Ensemble Transcript | ENST00000242351 [Q7Z2W4-1];ENST00000471652 [Q7Z2W4-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0003723, GO:0005634, GO:0005737, GO:0005829, GO:0009615, GO:0032727, GO:0032728, GO:0043123, GO:0045071, GO:0045087, GO:0045296, GO:0046872, GO:0051607, GO:0061014, GO:1900246, |
| MINT ID | Q7Z2W4 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 607312 |
| PANTHER ID | N.A. |
| PDB ID(s) | 2X5Y, 4X52, |
| pfam ID | PF00644, PF02825, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA |
| Author's Name | Chenhe Su, Jie Zhang and Chunfu Zheng |
| Journal Name | Virology Journal |
| Pubmed ID | 26625984 |
| Abstract | BACKGROUND: The zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the replication of various viruses by degradation of certain viral mRNA. However, previous study demonstrated that ectopic expression of rat ZAP did not suppress the replication of herpes simplex virus type 1 (HSV-1), an archetypal member of the alphaherpesvirus subfamily, and the molecular mechanism underneath is still illusive.RESULTS: Human ZAP (hZAP) does not suppress the replication of herpes simplex virus 1, and HSV-1 UL41 protein was identified as an antagonist of hZAP by degrading its mRNA. Infection of wild-type (WT), but not UL41-null mutant (R2621) virus, diminished the accumulation of hZAP to abrogate its antiviral activity. Moreover, ectopic expression of hZAP inhibited the replication of R2621 but not WT HSV-1. CONCLUSION: HSV-1 UL41 was shown for the first time to evade the antiviral function of hZAP via its RNase activity. |
| Used Model | HEK-293T, Vero and 293Trex-hZAPS cells |
| DOI | 10.1186/s12985-015-0433-y |
