| Gene Name | PDZD8 |
| HF Protein Name | PDZ domain-containing protein 8 |
| HF Function | Suppresses HSV-1 infection |
| Uniprot ID | Q8NEN9 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 118987 |
| Host Factor (HF) Name in Paper | PDZD8 |
| Gene synonyms | PDZK8 |
| Ensemble Gene ID | ENSG00000165650 |
| Ensemble Transcript | ENST00000334464 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005739, GO:0005789, GO:0006869, GO:0007010, GO:0008289, GO:0016020, GO:0016021, GO:0016032, GO:0022604, GO:0035556, GO:0044233, GO:0046872, GO:0051560, GO:1990456, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 614235 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF00130, PF00595, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | PDZD8 is a novel moesin-interacting cytoskeletal regulatory protein that suppresses infection by herpes simplex virus type 1 |
| Author's Name | Matthew S. Henning, Patricia Stiedl, Denis S. Barry, Robert McMahon, Scott G. Morham, Derek Walsh, Mojgan H. Naghavi |
| Journal Name | Virology |
| Pubmed ID | 21549406 |
| Abstract | The host cytoskeleton plays a central role in the life cycle of many viruses yet our knowledge of cytoskeletal regulators and their role in viral infection remains limited. Recently, moesin and ezrin, two members of the ERM (Ezrin/Radixin/Moesin) family of proteins that regulate actin and plasma membrane cross-linking and microtubule (MT) stability, have been shown to inhibit retroviral infection. To further understand how ERM proteins function and whether they also influence infection by other viruses, we identified PDZD8 as a novel moesin-interacting protein. PDZD8 is a poorly understood protein whose function is unknown. Exogenous expression of either moesin or PDZD8 reduced the levels of stable MTs, suggesting that these proteins functioned as part of a cytoskeletal regulatory complex. Additionally, exogenous expression or siRNA-mediated knockdown of either factor affected Herpes Simplex Virus type 1 (HSV-1) infection, identifying a cellular function for PDZD8 and novel antiviral properties for these two cytoskeletal regulatory proteins. |
| Used Model | HEK293 |
| DOI | 10.1016/j.virol.2011.04.006 |
