Download Help

Virus Details


VHFID3830

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name EGFR
HF Protein Name Epidermal growth factor receptor
HF Function Helps in the HSV 1 Entry into Neuronal Cells
Uniprot ID P00533
Protein Sequence View Fasta Sequence
NCBI Gene ID 1956
Host Factor (HF) Name in Paper EGFR
Gene synonyms ERBB ERBB1 HER1
Ensemble Gene ID ENSG00000146648
Ensemble Transcript ENST00000275493 [P00533-1];ENST00000342916 [P00533-4];ENST00000344576 [P00533-3];ENST00000420316 [P00533-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000139, GO:0000165, GO:0001503, GO:0001618, GO:0001892, GO:0001934, GO:0001942, GO:0003682, GO:0003690, GO:0004709, GO:0004713, GO:0004714, GO:0004716, GO:0004888, GO:0005006, GO:0005088, GO:0005178, GO:0005516, GO:0005524, GO:0005615, GO:0005634, GO:0005737, GO:0005768, GO:0005789, GO:0005886, GO:0005925, GO:0006357, GO:0006412, GO:0006970, GO:0007165, GO:0007166, GO:0007173, GO:0007202, GO:0007435, GO:0007494, GO:0007611, GO:0007623, GO:0008283, GO:0008284, GO:0009986, GO:0010008, GO:0010750, GO:0010960, GO:0014066, GO:0016020, GO:0016021, GO:0016101, GO:0016323, GO:0016324, GO:0018108, GO:0019899, GO:0019901, GO:0019903, GO:0021795, GO:0030139, GO:0030307, GO:0030324, GO:0030335, GO:0030665, GO:0031625, GO:0031659, GO:0031901, GO:0031965, GO:0032930, GO:0032991, GO:0033138, GO:0033590, GO:0033594, GO:0034614, GO:0035413, GO:0038083, GO:0038128, GO:0042059, GO:0042060, GO:0042177, GO:0042327, GO:0042698, GO:0042743, GO:0042802, GO:0043006, GO:0043066, GO:0043235, GO:0043406, GO:0,
MINT ID P00533
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 131550
PANTHER ID N.A.
PDB ID(s) 1DNQ, 1DNR, 1IVO, 1M14, 1M17, 1MOX, 1NQL, 1XKK, 1YY9, 1Z9I, 2EB2, 2EB3, 2EXP, 2EXQ, 2GS2, 2GS6, 2GS7, 2ITN, 2ITO, 2ITP, 2ITQ, 2ITT, 2ITU, 2ITV, 2ITW, 2ITX, 2ITY, 2ITZ, 2J5E, 2J5F, 2J6M, 2JIT, 2JIU, 2JIV, 2KS1, 2M0B, 2M20, 2N5S, 2RF9, 2RFD, 2RFE, 2RGP, 3B2U, 3B2V, 3BEL, 3BUO, 3C09, 3G5V, 3G5Y, 3GOP, 3GT8, 3IKA, 3LZB, 3NJP, 3OB2, 3OP0, 3P0Y, 3PFV, 3POZ, 3QWQ, 3UG1, 3UG2, 3VJN, 3VJO, 3VRP, 3VRR, 3W2O, 3W2P, 3W2Q, 3W2R, 3W2S, 3W32, 3W33, 4G5J, 4G5P, 4HJO, 4I1Z, 4I20, 4I21, 4I22, 4I23, 4I24, 4JQ7, 4JQ8, 4JR3, 4JRV, 4KRL, 4KRM, 4KRO, 4KRP, 4LI5, 4LL0, 4LQM, 4LRM, 4R3P, 4R3R, 4R5S, 4RIW, 4RIX, 4RIY, 4RJ4, 4RJ5, 4RJ6, 4RJ7, 4RJ8, 4TKS, 4UIP, 4UV7, 4WD5, 4WKQ, 4WRG, 4ZAU, 4ZJV, 4ZSE, 5C8K, 5C8M, 5C8N, 5CAL, 5CAN, 5CAO, 5CAP, 5CAQ, 5CAS, 5CAU, 5CAV, 5CNN, 5CNO, 5CZH, 5CZI, 5D41, 5EDP, 5EDQ, 5EDR, 5EM5, 5EM6, 5EM7, 5EM8, 5FED, 5FEE, 5FEQ, 5GMP, 5GNK, 5GTY, 5GTZ, 5HCX, 5HCY, 5HCZ, 5HG5, 5HG7, 5HG8, 5HG9, 5HIB, 5HIC, 5J9Y, 5J9Z, 5JEB, 5LV6, 5SX4, 5SX5, 5U8L, 5UG8, 5UG9, 5UGA, 5UGB, 5UGC, 5UWD, 5WB7, 5WB8, 5X26, 5X27, 5X28, 5X2A, 5X2C, 5X2F, 5X2K, 5XDK, 5XDL, 5XGM, 5XGN, 5XWD, 5YU9, 6B3S,
pfam ID PF00757, PF14843, PF07714, PF01030,
Drug Bank ID DB08916, DB00002, DB05424, DB00530, DB03496, DB00317, DB05324, DB11737, DB04988, DB05774, DB05900, DB01259, DB00281, DB05101, DB07662, DB09559, DB13164, DB09330, DB01269, DB05374, DB07602, DB00072, DB05294,
ChEMBL ID CHEMBL203
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human herpesvirus 1
Virus Short Name HSV1
Order Herpesvirales
Virus Family Herpesviridae
Virus Subfamily Alphaherpesvirinae
Genus Simplexvirus
Species Herpes simplex virus 1
Host Human, mammals
Cell Tropism Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions)
Associated Disease Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis
Mode of Transmission Contact, saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae

Publication Information

Paper Title Epidermal Growth Factor Receptor-PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells
Author's Name Kai Zheng, Yangfei Xiang, Xiao Wang, Qiaoli Wang, Meigong Zhong, Shaoxiang Wang, Xiaoyan Wang, Jianglin Fan, Kaio Kitazato, Yifei Wanga
Journal Name mBio-American Society of Microbiology
Pubmed ID 24425731
Abstract Herpes simplex virus type 1 (HSV-1) establishes latency in neurons and can cause severe disseminated infection with neurological impairment and high mortality. This neurodegeneration is thought to be tightly associated with virus-induced cytoskeleton disruption. Currently, the regulation pattern of the actin cytoskeleton and the involved molecular mechanisms during HSV-1 entry into neurons remain unclear. Here, we demonstrate that the entry of HSV-1 into neuronal cells induces biphasic remodeling of the actin cytoskeleton and an initial inactivation followed by the subsequent activation of cofilin, a member of the actin depolymerizing factor family that is critical for actin reorganization. The disruption of F-actin dynamics or the modulation of cofilin activity by mutation, knockdown, or overexpression affects HSV-1 entry efficacy and virus-mediated cell ruffle formation. Binding of the HSV-1 envelope initiates the epidermal growth factor receptor (EGFR)-phosphatidylinositide 3-kinase (PI3K) signaling pathway, which leads to virus-induced early cofilin phosphorylation and F-actin polymerization. Moreover, the extracellular signal-regulated kinase (ERK) kinase and Rho-associated, coiled-coil-containing protein kinase 1 (ROCK) are recruited as downstream mediators of the HSV-1-induced cofilin inactivation pathway. Inhibitors specific for those kinases significantly reduce the virus infectivity without affecting virus binding to the target cells. Additionally, lipid rafts are clustered to promote EGFR-associated signaling cascade transduction. We propose that HSV-1 hijacks cofilin to initiate infection. These results could promote a better understanding of the pathogenesis of HSV-1-induced neurological diseases.
Used Model SK? N?SH cells
DOI 10.1128/mBio.00958-13