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Virus Details


VHFID3832

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name TNF
HF Protein Name Tumor necrosis factor
HF Function Plays a protective role in acute infection with HSV-2
Uniprot ID P01375
Protein Sequence View Fasta Sequence
NCBI Gene ID 7124
Host Factor (HF) Name in Paper TNF-alpha
Gene synonyms TNFA TNFSF2
Ensemble Gene ID ENSG00000204490
Ensemble Transcript ENST00000376122;ENST00000383496;ENST00000412275;ENST00000420425;ENST00000443707;ENST00000448781;ENST00000449264
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000060, GO:0000122, GO:0000165, GO:0000185, GO:0000187, GO:0001819, GO:0001891, GO:0001934, GO:0001937, GO:0002020, GO:0002439, GO:0002740, GO:0002876, GO:0002925, GO:0005125, GO:0005164, GO:0005576, GO:0005615, GO:0005886, GO:0005887, GO:0006006, GO:0006919, GO:0006954, GO:0006959, GO:0007249, GO:0007254, GO:0008625, GO:0008630, GO:0009615, GO:0009651, GO:0009897, GO:0009986, GO:0010628, GO:0010629, GO:0010693, GO:0010803, GO:0010888, GO:0019221, GO:0030198, GO:0030316, GO:0030730, GO:0030866, GO:0031334, GO:0031622, GO:0031663, GO:0032715, GO:0032722, GO:0032729, GO:0032755, GO:0032757, GO:0032800, GO:0033138, GO:0033209, GO:0034116, GO:0035509, GO:0042346, GO:0042802, GO:0043065, GO:0043068, GO:0043122, GO:0043123, GO:0043242, GO:0043243, GO:0043280, GO:0043406, GO:0043491, GO:0043507, GO:0044130, GO:0044212, GO:0045071, GO:0045080, GO:0045121, GO:0045416, GO:0045429, GO:0045599, GO:0045662, GO:0045668, GO:0045672, GO:0045732, GO:0045785, GO:0045860, GO:0045892, GO:0045893, GO:0,
MINT ID P01375
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 191160
PANTHER ID PTHR11471:SF23
PDB ID(s) 1A8M, 1TNF, 2AZ5, 2E7A, 2TUN, 2ZJC, 2ZPX, 3ALQ, 3IT8, 3L9J, 3WD5, 4G3Y, 4TSV, 4TWT, 4Y6O, 5M2I, 5M2J, 5M2M, 5MU8, 5TSW, 5UUI, 5WUX,
pfam ID PF00229,
Drug Bank ID DB05250, DB00051, DB04956, DB05879, DB01427, DB05676, DB05066, DB08904, DB00608, DB01407, DB05744, DB05869, DB05758, DB00668, DB00005, DB01296, DB06674, DB05767, DB00065, DB02325, DB05303, DB05218, DB08910, DB01411, DB00852, DB05412, DB05207, DB01041, DB05470, DB05017,
ChEMBL ID CHEMBL1825
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human herpesvirus 1
Virus Short Name HSV1
Order Herpesvirales
Virus Family Herpesviridae
Virus Subfamily Alphaherpesvirinae
Genus Simplexvirus
Species Herpes simplex virus 1
Host Human, mammals
Cell Tropism Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions)
Associated Disease Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis
Mode of Transmission Contact, saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae

Publication Information

Paper Title Role of IFN-g and Tumor Necrosis Factor-a in Herpes Simplex Virus Type 1 Infection
Author's Name Masato Minami, Masakazu Kita, Xiao-Qun Yan, Toshiro Yamamoto, Tohko Iida, Kenji Sekikawa, Yoichiro Iwakura, Jiro Imanishi
Journal Name Journal Of Interferon and Cytokine Research
Pubmed ID 12162877
Abstract One of the characteristics of herpes simplex virus type 1 (HSV-1) is that recurrent diseases often develop from latent infection established after acute infection. Cytokines have been proposed to play an important role in each stage of HSV-1 infection, but the exact role of cytokines remains unclear. In the present study, we investigated the role of interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) in acute infection and reactivation using IFN-gamma gene knockout (IFN-gamma(-/-)) mice and TNF-alpha gene knockout (TNF-alpha(-/-)) mice. We first examined the survival rate after corneal infection with HSV-1. The survival rates of wild-type C57BL/6 (B6) mice, IFN-gamma(-/-) mice, and TNF-alpha(-/-) mice were 97% (73 of 75), 57% (24 of 42), and 83% (60 of 72), respectively. These results suggest that TNF-alpha and IFN-gamma play a protective role in acute infection with HSV-1. We also examined the rate of reactivation induced by ultraviolet (UV) light in latently infected mice over 60 days postinoculation. The reactivation was confirmed by detecting viral DNA extracted from eyeballs by the polymerase chain reaction (PCR) method at day 2 after the UV light stimulation. The rates of reactivation in IFN-gamma(-/-) mice and TNF-alpha(-/-) mice were significantly higher than that in B6 mice 16% (4 of 25) showed reactivation in B6 mice, 47% (9 of 19) in IFN-gamma(-/-) mice, and 48% (10 of 21) in TNF-alpha(-/-) mice. These results suggest that IFN-gamma and TNF-alpha play an important role in acute infection and reactivation from latency.
Used Model C57BL/6CrSIC (B6) mice
DOI 10.1089/10799900260100150