| Gene Name | SRSF2 |
| HF Protein Name | Serine/arginine-rich splicing factor 2 |
| HF Function | Essential for virus replication, SRSF2 participates in ICP0 pre-mRNA splicing |
| Uniprot ID | Q01130 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 6427 |
| Host Factor (HF) Name in Paper | SRSF2 |
| Gene synonyms | SFRS2 |
| Ensemble Gene ID | ENSG00000119383 |
| Ensemble Transcript | ENST00000359995 [Q01130-1];ENST00000392485 [Q01130-1];ENST00000452355 [Q01130-1];ENST00000508921 [Q01130-2];ENST00000585202 [Q01130-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000278, GO:0000381, GO:0000398, GO:0003714, GO:0003723, GO:0005080, GO:0005634, GO:0005654, GO:0005681, GO:0005829, GO:0006369, GO:0006397, GO:0006405, GO:0006406, GO:0008380, GO:0016607, GO:0031124, GO:0033197, GO:0035061, GO:0036002, GO:0070062, |
| MINT ID | Q01130 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 600813 |
| PANTHER ID | PTHR23147:SF16 |
| PDB ID(s) | 2KN4, 2LEA, 2LEB, 2LEC, |
| pfam ID | PF00076, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Serine/Arginine-rich Splicing Factor 2 Modulates Herpes Simplex Virus Type 1 Replication via Regulating Viral Gene Transcriptional Activity and Pre-mRNA Splicing |
| Author's Name | Ziqiang Wang, Qing Liu, Jinhua Lu, Ping Fan, Weidong Xie, Wei Qiu, Fan Wang, Guangnan Hu and Yaou Zhang |
| Journal Name | The Journal Of Biological Chemistry |
| Pubmed ID | 27784784 |
| Abstract | Once it enters the host cell, herpes simplex virus type 1 (HSV-1) recruits a series of host cell factors to facilitate its life cycle. Here, we demonstrate that serine/arginine-rich splicing factor 2 (SRSF2), which is an important component of the splicing speckle, mediates HSV-1 replication by regulating viral gene expression at the transcriptional and posttranscriptional levels. Our results indicate that SRSF2 functions as a transcriptional activator by directly binding to infected cell polypeptide 0 (ICP0), infected cell polypeptide 27 (ICP27), and thymidine kinase promoters. Moreover, SRSF2 participates in ICP0 pre-mRNA splicing by recognizing binding sites in ICP0 exon 3. These findings provide insight into the functions of SRSF2 in HSV-1 replication and gene expression. |
| Used Model | HeLa cells |
| DOI | 10.1074/jbc.M116.753046 |
