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Virus Details


VHFID3929

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name TP53
HF Protein Name Cellular tumor antigen p53
HF Function Promotes HSV-1 replication
Uniprot ID P04637
Protein Sequence View Fasta Sequence
NCBI Gene ID 7157
Host Factor (HF) Name in Paper p53
Gene synonyms P53
Ensemble Gene ID ENSG00000141510
Ensemble Transcript ENST00000269305 [P04637-1];ENST00000420246 [P04637-2];ENST00000445888 [P04637-1];ENST00000455263 [P04637-3];ENST00000504290 [P04637-9];ENST00000504937 [P04637-7];ENST00000510385 [P04637-8];ENST00000610292 [P04637-4];ENST00000610538 [P04637-6];ENST00000617185 [P04637-2];ENST00000619485 [P04637-4];ENST00000620739 [P04637-4];ENST00000622645 [P04637-5]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000733, GO:0000790, GO:0000978, GO:0000981, GO:0000990, GO:0001046, GO:0001074, GO:0001084, GO:0001085, GO:0001094, GO:0001228, GO:0002020, GO:0002039, GO:0003677, GO:0003682, GO:0003684, GO:0003700, GO:0003730, GO:0005507, GO:0005524, GO:0005622, GO:0005634, GO:0005654, GO:0005657, GO:0005730, GO:0005737, GO:0005739, GO:0005759, GO:0005783, GO:0005829, GO:0006284, GO:0006289, GO:0006355, GO:0006914, GO:0006974, GO:0006977, GO:0006978, GO:0006983, GO:0007050, GO:0007265, GO:0007275, GO:0007569, GO:0008104, GO:0008134, GO:0008270, GO:0008283, GO:0008285, GO:0008340, GO:0009299, GO:0010165, GO:0010332, GO:0010628, GO:0016032, GO:0016363, GO:0016579, GO:0016605, GO:0019221, GO:0019899, GO:0019901, GO:0019903, GO:0030154, GO:0030308, GO:0030330, GO:0030971, GO:0031065, GO:0031497, GO:0031571, GO:0031625, GO:0032461, GO:0032991, GO:0034613, GO:0034644, GO:0035035, GO:0035690, GO:0042149, GO:0042771, GO:0042802, GO:0042826, GO:0042981, GO:0043065, GO:0043066, GO:0043153, GO:0,
MINT ID P04637
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 133239
PANTHER ID PTHR11447
PDB ID(s) 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1JSP, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2F1X, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MWY, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4QO1, 4RP6, 4RP7, 4X34, 4XR8, 4ZZJ, 5A7B, 5AB9, 5ABA, 5AOI, 5AOJ, 5AOK, 5AOL, 5AOM, 5BUA, 5ECG, 5G4M, 5G4N, 5G4O, 5HOU, 5HP0, 5HPD, 5LAP, 5LGY, 5MHC, 5MOC, 5OL0, 5UN8,
pfam ID PF00870, PF08563, PF07710,
Drug Bank ID DB08363, DB00945, DB05404,
ChEMBL ID CHEMBL4096
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human herpesvirus 1
Virus Short Name HSV1
Order Herpesvirales
Virus Family Herpesviridae
Virus Subfamily Alphaherpesvirinae
Genus Simplexvirus
Species Herpes simplex virus 1
Host Human, mammals
Cell Tropism Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions)
Associated Disease Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis
Mode of Transmission Contact, saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae

Publication Information

Paper Title Roles of p53 in herpes simplex virus 1 replication
Author's Name Yuhei Maruzuru, Hikaru Fujii, Masaaki Oyama, Hiroko Kozuka-Hata, Akihisa Kato, Yasushi Kawaguch
Journal Name Journal Of Virology
Pubmed ID 23785201
Abstract p53 is a critical factor in the cellular response to a broad range of stress factors through its ability to regulate various cellular pathways. In this study, tandem affinity purification of transiently expressed herpes simplex virus 1 (HSV-1) regulatory protein ICP22 coupled with mass spectrometry-based proteomics technology and subsequent analyses showed that ICP22 interacted with p53 in HSV-1-infected cells. In p53(-/-) cells, replication of wild-type HSV-1 was reduced compared to that in parental p53(+/+) cells, indicating that p53 had a positive effect on HSV-1 replication. In contrast, the levels of viral replication of an ICP22-null mutant virus were similar in both p53(-/-) and p53(+/+) cells. At 2 h postinfection, the level of expression of ICP27, an essential viral regulatory protein, in p53(-/-) cells infected with wild-type HSV-1 or the ICP22-null mutant virus was lower than in p53(+/+) cells. In contrast, at 18 h postinfection, the level of expression of ICP0, a critical viral regulatory protein, in p53(-/-) cells infected with the ICP22-null mutant virus was higher than in p53(+/+) cells, although the levels of ICP0 expression in p53(-/-) and p53(+/+) cells infected with wild-type HSV-1 were almost identical. These results suggested that p53 overall promoted HSV-1 replication and that p53 played both positive and negative roles in HSV-1 replication: upregulating ICP27 expression very early in infection and downregulating ICP0 expression later in infection, which was antagonized by ICP22.
Used Model HEL, 293T, VERO and HCT116 cells
DOI 10.1128/JVI.01581-13