| Gene Name | IFIT3 |
| HF Protein Name | Interferon-induced protein with tetratricopeptide repeats 3 |
| HF Function | Antiviral protein |
| Uniprot ID | O14879 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3437 |
| Host Factor (HF) Name in Paper | IFIT3 |
| Gene synonyms | CIG-49 IFI60 IFIT4 ISG60 |
| Ensemble Gene ID | ENSG00000119917 |
| Ensemble Transcript | ENST00000371811;ENST00000371818 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005737, GO:0005739, GO:0005829, GO:0008285, GO:0009615, GO:0035457, GO:0042802, GO:0043066, GO:0051607, GO:0060337, |
| MINT ID | O14879 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 604650 |
| PANTHER ID | PTHR10271:SF3 |
| PDB ID(s) | N.A., |
| pfam ID | PF13176, PF13181, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Herpes Simplex Virus 1 Tegument Protein UL41 Counteracts IFIT3 Antiviral Innate Immunity |
| Author's Name | Zhangtao Jiang, Chenhe Su, Chunfu Zheng |
| Journal Name | Journal Of Virology |
| Pubmed ID | 27681138 |
| Abstract | The interferon-induced protein with tetratricopeptide repeat 3 (IFIT3 or ISG60) is a host-intrinsic antiviral factor that restricts many instances of DNA and RNA virus replication. Herpes simplex virus 1 (HSV-1), a DNA virus bearing a large genome, can encode many viral proteins to counteract the host immune responses. However, whether IFIT3 plays a role upon HSV-1 infection is little known. In this study, we show for the first time that HSV-1 tegument protein UL41, a viral endoribonuclease, plays an important role in inhibiting the antiviral activity of IFIT3. Here, we demonstrated that ectopically expressed IFIT3 could restrict the replication of vesicular stomatitis virus (VSV) but had little effect on the replication of wild-type (WT) HSV-1. Further study showed that WT HSV-1 infection downregulated the expression of IFIT3, and ectopic expression of UL41, but not the immediate-early protein ICP0, notably reduced the expression of IFIT3. The underlying molecular mechanism was that UL41 diminished the accumulation of IFIT3 mRNA to abrogate its antiviral activity. In addition, our results illustrated that ectopic expression of IFIT3 inhibited the replication of UL41-null mutant virus (R2621), and stable knockdown of IFIT3 facilitated its replication. Taking these findings together, HSV-1 was shown for the first time to evade the antiviral function of IFIT3 via UL41. |
| Used Model | HEK293T,HEK293, and Vero cells |
| DOI | 10.1128/JVI.01672-16 |
