| Gene Name | RNF168 |
| HF Protein Name | E3 ubiquitin-protein ligase RNF168 |
| HF Function | Negatively control virus replication |
| Uniprot ID | Q8IYW5 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 165918 |
| Host Factor (HF) Name in Paper | RNF168 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000163961 |
| Ensemble Transcript | ENST00000318037 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000151, GO:0003682, GO:0004842, GO:0005634, GO:0005654, GO:0005829, GO:0006302, GO:0006303, GO:0006511, GO:0006974, GO:0010212, GO:0016567, GO:0031491, GO:0032991, GO:0034244, GO:0035518, GO:0035861, GO:0036297, GO:0036351, GO:0036352, GO:0042393, GO:0043130, GO:0045190, GO:0045739, GO:0046872, GO:0070530, GO:0070534, GO:0070535, |
| MINT ID | Q8IYW5 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 611943 |
| PANTHER ID | N.A. |
| PDB ID(s) | 3L11, 4GB0, 5XIS, 5XIT, 5XIU, 5YDK, |
| pfam ID | N.A., |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Selective recruitment of host factors by HSV-1 replication centers |
| Author's Name | Feng-Chao LANG, Xin LI, Olga VLADMIROVA, Zhuo-Ran LI, Gui-Jun CHEN, Yu XIAO, Li-Hong LI, Dan-Feng LU, Hong-Bo HAN, Ju-Min ZHOU |
| Journal Name | Zoological Research |
| Pubmed ID | 26018857 |
| Abstract | Herpes simplex virus type 1 (HSV-1) enters productive infection after infecting epithelial cells, where it controls the host nucleus to make viral proteins, starts viral DNA synthesis and assembles infectious virions. In this process, replicating viral genomes are organized into replication centers to facilitate viral growth. HSV-1 is known to use host factors, including host chromatin and host transcription regulators, to transcribe its genes however, the invading virus also encounters host defense and stress responses to inhibit viral growth. Recently, we found that HSV-1 replication centers recruit host factor CTCF but exclude gammaH2A.X. Thus, HSV-1 replication centers may selectively recruit cellular factors needed for viral growth, while excluding host factors that are deleterious for viral transcription or replication. Here we report that the viral replication centers selectively excluded modified histone H3, including heterochromatin mark H3K9me3, H3S10P and active chromatin mark H3K4me3, but not unmodified H3. We found a dynamic association between the viral replication centers and host RNA polymerase II. The centers also recruited components of the DNA damage response pathway, including 53BP1, BRCA1 and host antiviral protein SP100. Importantly, we found that ATM kinase was needed for the recruitment of CTCF to the viral centers. These results suggest that the HSV-1 replication centers took advantage of host signaling pathways to actively recruit or exclude host factors to benefit viral growth. |
| Used Model | BJ, HeLa, 293T and Vero cells |
| DOI | N.A. |
