Hostfactor - VHFIDB

Gene Name	NECTIN1
HF Protein Name	Nectin-1
HF Function	Receptor for viral entry
Uniprot ID	Q15223
Protein Sequence	View Fasta Sequence
NCBI Gene ID	5818
Host Factor (HF) Name in Paper	Prr1
Gene synonyms	HVEC PRR1 PVRL1
Ensemble Gene ID	ENSG00000110400
Ensemble Transcript	ENST00000264025 [Q15223-1];ENST00000340882 [Q15223-3];ENST00000341398 [Q15223-2]
KEGG ID	Go to KEGG Database
Gene Ontology ID(s)	GO:0001618, GO:0002089, GO:0002934, GO:0005102, GO:0005576, GO:0005886, GO:0005887, GO:0005912, GO:0005913, GO:0006826, GO:0006955, GO:0007155, GO:0007156, GO:0007157, GO:0007411, GO:0008037, GO:0015026, GO:0016020, GO:0016021, GO:0016342, GO:0030246, GO:0032584, GO:0034332, GO:0042734, GO:0042802, GO:0042803, GO:0043231, GO:0043296, GO:0044291, GO:0046718, GO:0046790, GO:0046982, GO:0050839, GO:0051963, GO:0060041, GO:0070166, GO:0098609, GO:1902414,
MINT ID	Q15223
STRING	Click to see interaction map
GWAS Analysis	Click to see gwas analysis
OMIM ID	225060
PANTHER ID	PTHR23277:SF69
PDB ID(s)	3ALP, 3SKU, 3U82, 3U83, 4FMF, 4MYW,
pfam ID	PF08205, PF07686,
Drug Bank ID	N.A.,
ChEMBL ID	N.A.
Organism	Homo sapiens (Human)

Virus Name	Human herpesvirus 1
Virus Short Name	HSV1
Order	Herpesvirales
Virus Family	Herpesviridae
Virus Subfamily	Alphaherpesvirinae
Genus	Simplexvirus
Species	Herpes simplex virus 1
Host	Human, mammals
Cell Tropism	Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions)
Associated Disease	Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis
Mode of Transmission	Contact, saliva
VIPR DB link	http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes
ICTV DB link	https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae
Virus Host DB link	http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae

Paper Title	entry of alphaherpesviruses mediated by poliovirus receptor related protein 1 and polio virus receptor
Author's Name	Robert J. Geraghty, Claude Krummenacher, Gary H. Cohen, Roselyn J. Eisenberg, Patricia G. Spear
Journal Name	SCIENCE
Pubmed ID	9616127
Abstract	A human member of the immunoglobulin superfamily was shown to mediate entry of several alphaherpesviruses, including herpes simplex viruses (HSV) 1 and 2, porcine pseudorabies virus (PRV), and bovine herpesvirus 1 (BHV-1). This membrane glycoprotein is poliovirus receptor-related protein 1 (Prr1), designated here as HveC. Incubation of HSV-1 with a secreted form of HveC inhibited subsequent infection of a variety of cell lines, suggesting that HveC interacts directly with the virus. Poliovirus receptor (Pvr) itself mediated entry of PRV and BHV-1 but not of the HSV strains tested. HveC was expressed in human cells of epithelial and neuronal origin it is the prime candidate for the coreceptor that allows both HSV-1 and HSV-2 to infect epithelial cells on mucosal surfaces and spread to cells of the nervous system.
Used Model	CHO and HeLa cells
DOI	10.1126/science.280.5369.1618

Virus Details