Virus Details


VHFID3940

Pathogen Information

Virus Name Human herpesvirus 1
Virus Short Name HSV1
Order Herpesvirales
Virus Family Herpesviridae
Virus Subfamily Alphaherpesvirinae
Genus Simplexvirus
Species Herpes simplex virus 1
Host Human, mammals
Cell Tropism Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions)
Associated Disease Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis
Mode of Transmission Contact, saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae

Publication Information

Paper Title A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus Type 1, herpes simplex virus Type 2, and pseudorabies virus
Author's Name Morgyn S. Warner, Robert J. Geraghty, Wanda M. Martinez, Rebecca I. Montgomery, J. Charles Whitbeck, Ruliang Xu, Roselyn J. Eisenberg, Gary H. Cohen, and Patricia G. Spear
Journal Name Virology
Pubmed ID 9657005
Abstract Certain mutant strains of herpes simplex virus type 1 (HSV-1) are unable to infect cells in which entry is dependent on HVEM, the previously described herpesvirus entry mediator designated here as herpesvirus entry protein A (HveA). These mutant viruses can infect other cells where entry is apparently dependent on other co-receptors. The mutant virus HSV-1(KOS)Rid1 was used to screen a human cDNA expression library for ability of transfected plasmids to convert resistant Chinese hamster ovary cells to susceptibility to virus entry. A plasmid expressing the previously described poliovirus receptor-related protein 2 (Prr2) was isolated on the basis of this activity. This protein, designated here as HveB, was shown to mediate the entry of three mutant HSV-1 strains that cannot use HVEM as co-receptor, but not wild-type HSV-1 strains. HveB also mediated the entry of HSV-2 and pseudorabies virus but not bovine herpesvirus type 1. HveB was expressed in some human neuronal cell lines, fibroblastic cells, keratinocytes, and primary activated T lymphocytes. Antibodies specific for HveB blocked infection of HveB-expressing CHO cells and a human fibroblastic cell strain HEL299. Differences in ability of HSV-1 and HSV-2 strains to use HveB for entry should influence the types of cells that can be infected and thereby account in part for serotype and strain differences in tissue tropism and pathogenicity.
Used Model CHO cells
DOI 10.1006/viro.1998.9218