| Gene Name | PILRA |
| HF Protein Name | Paired immunoglobulin-like type 2 receptor alpha |
| HF Function | Cellular co-receptor for virus entry |
| Uniprot ID | Q9UKJ1 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 29992 |
| Host Factor (HF) Name in Paper | PILRalpha |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000085514 |
| Ensemble Transcript | ENST00000198536 [Q9UKJ1-1];ENST00000350573 [Q9UKJ1-3];ENST00000394000 [Q9UKJ1-4] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005886, GO:0007165, GO:0007169, GO:0016021, GO:0016032, GO:0042288, GO:0050776, GO:0070062, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605341 |
| PANTHER ID | N.A. |
| PDB ID(s) | 3WUZ, 3WV0, 4NFB, 5XO2, 5XOF, |
| pfam ID | PF07686, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B |
| Author's Name | Takeshi Satoh, Jun Arii, Tadahiro Suenaga, Jing Wang, Amane Kogure, Junji Uehori, Noriko Arase, Ikuo Shiratori, Shinya Tanaka, Yasushi Kawaguchi, Patricia G. Spear, Lewis L. Lanier, and Hisashi Arase |
| Journal Name | Cell |
| Pubmed ID | 18358807 |
| Abstract | Glycoprotein B (gB) is one of the essential components for infection by herpes simplex virus-1 (HSV-1). Although several cellular receptors that associate with glycoprotein D (gD), such as herpes virus entry mediator (HVEM) and Nectin-1, have been identified, specific molecules that mediate HSV-1 infection by associating with gB have not been elucidated. Here, we found that paired immunoglobulin-like type 2 receptor (PILR) alpha associates with gB, and cells transduced with PILRalpha become susceptible to HSV-1 infection. Furthermore, HSV-1 infection of human primary cells expressing both HVEM and PILRalpha was blocked by either anti-PILRalpha or anti-HVEM antibody. Our results demonstrate that cellular receptors for both gB and gD are required for HSV-1 infection and that PILRalpha plays an important role in HSV-1 infection as a coreceptor that associates with gB. These findings uncover a crucial aspect of the mechanism underlying HSV-1 infection. |
| Used Model | 293T,NIH 3T3 cells and Vero cells |
| DOI | 10.1016/j.cell.2008.01.043 |
