| Gene Name | ITGB6 |
| HF Protein Name | Toll-like receptor 9 |
| HF Function | Receptor for viral entry |
| Uniprot ID | P18564 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3694 |
| Host Factor (HF) Name in Paper | beta6 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000115221 |
| Ensemble Transcript | ENST00000283249 [P18564-1];ENST00000409872 [P18564-1];ENST00000409967 [P18564-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0004872, GO:0005178, GO:0005654, GO:0005813, GO:0005886, GO:0005925, GO:0006954, GO:0007155, GO:0007160, GO:0007229, GO:0008305, GO:0009897, GO:0030054, GO:0030198, GO:0033627, GO:0034685, GO:0038044, GO:0043235, GO:0070062, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 147558 |
| PANTHER ID | PTHR10082;PTHR10082:SF11 |
| PDB ID(s) | 1LH9, 4UM8, 4UM9, 5FFG, 5FFO, 5NEM, 5NER, 5NET, 5NEU, |
| pfam ID | PF07974, PF08725, PF07965, PF00362, PF17205, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL2111416 |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 1 |
| Virus Short Name | HSV1 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 1 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | avb6- and avb8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion |
| Author's Name | Tatiana Gianni, Stefano Salvioli, Liudmila S. Chesnokova, Lindsey M. Hutt-Fletcher, Gabriella Campadelli-Fiume |
| Journal Name | PLOS Pathogens |
| Pubmed ID | 24367260 |
| Abstract | Herpes simplex virus (HSV)--and herpesviruses in general--encode for a multipartite entry/fusion apparatus. In HSV it consists of the HSV-specific glycoprotein D (gD), and three additional glycoproteins, gH/gL and gB, conserved across the Herpesviridae family and responsible for the execution of fusion. According to the current model, upon receptor binding, gD propagates the activation to gH/gL and to gB in a cascade fashion. Questions remain about how the cascade of activation is controlled and how it is synchronized with virion endocytosis, to avoid premature activation and exhaustion of the glycoproteins. We considered the possibility that such control might be carried out by as yet unknown receptors. Indeed, receptors for HSV gB, but not for gH/gL, have been described. In other members of the Herpesviridae family, such as Epstein-Barr virus, integrin receptors bind gH/gL and trigger conformational changes in the glycoproteins. We report that alphavbeta6- and alphavbeta8-integrins serve as receptors for HSV entry into experimental models of keratinocytes and other epithelial and neuronal cells. Evidence rests on loss of function experiments, in which integrins were blocked by antibodies or silenced, and gain of function experiments in which alphavbeta6-integrin was expressed in integrin-negative cells. alphavbeta6- and alphavbeta8-integrins acted independently and are thus interchangeable. Both bind gH/gL with high affinity. The interaction profoundly affects the route of HSV entry and directs the virus to acidic endosomes. In the case of alphavbeta8, but not alphavbeta6-integrin, the portal of entry is located at lipid microdomains and requires dynamin 2. Thus, a major role of alphavbeta6- or alphavbeta8-integrin in HSV infection appears to be to function as gH/gL receptors and to promote virus endocytosis. We propose that placing the gH/gL activation under the integrin trigger point enables HSV to synchronize virion endocytosis with the cascade of glycoprotein activation that culminates in execution of fusion. |
| Used Model | 293T, HeLa and SK-N-SH cells |
| DOI | 10.1371/journal.ppat.1003806 |
