| Gene Name | TNFRSF14 |
| HF Protein Name | Tumor necrosis factor receptor superfamily member 14 |
| HF Function | Receptor for viral entry |
| Uniprot ID | Q92956 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 8764 |
| Host Factor (HF) Name in Paper | HVEM |
| Gene synonyms | HVEA HVEM |
| Ensemble Gene ID | ENSG00000157873 |
| Ensemble Transcript | ENST00000355716 [Q92956-1];ENST00000621877 [Q92956-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0005031, GO:0005886, GO:0005887, GO:0006954, GO:0006955, GO:0007166, GO:0007275, GO:0031295, GO:0031625, GO:0032496, GO:0033209, GO:0042127, GO:0042981, GO:0097190, |
| MINT ID | Q92956 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 602746 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1JMA, 2AW2, 4FHQ, 4RSU, |
| pfam ID | PF00020, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 2 |
| Virus Short Name | HSV2 |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Alphaherpesvirinae |
| Genus | Simplexvirus |
| Species | Herpes simplex virus 2 |
| Host | Human, mammals |
| Cell Tropism | Primary site of infection: epithelial mucosal cells , latency: remains latent in sensory neurons (ganglions) |
| Associated Disease | Skin vesicles or mucosal ulcers, rarely encephalitis and meningitis |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes |
| Author's Name | Andrew H. Karaba, Sarah J. Kopp, and Richard Longnecker |
| Journal Name | PNAS |
| Pubmed ID | 23184983 |
| Abstract | Infection with herpes simplex virus type 1 (HSV-1) and HSV-2 is initiated by viral glycoprotein D (gD) binding to a receptor on the host cell. Two receptors, herpesvirus entry mediator (HVEM) and nectin-1, mediate entry in murine models of HSV-1 and HSV-2. HVEM is dispensable for HSV-2 infection of the vagina and brain, but is required for WT pathogenesis of HSV-1 infection of the cornea. By challenging WT and HVEM KO mice with multiple strains of HSV-1 and HSV-2, we demonstrate that without HVEM, all HSV-1 strains tested do not replicate well in the cornea and infection does not result in severe symptoms, as observed in WT mice. In contrast, all HSV-2 strains tested had no requirement for HVEM to replicate to WT levels in the cornea and still cause severe disease. These findings imply that HSV-2 does not require HVEM to cause disease regardless of route of entry, but HVEM must be present for HSV-1 to cause full pathogenesis in the eye. These findings uncover a unique role for HVEM in mediating HSV-1 infection in an area innervated by the trigeminal ganglion and may explain why the presence of HVEM can lead to severe inflammation in the cornea. Thus, the dependence on HVEM is a dividing point between HSV-1 and HSV-2 that evolved to infect areas innervated by different sensory ganglia. |
| Used Model | WT C57BL/6 and Tnfrsf14?/? (HVEM KO) mice |
| DOI | 10.1073/pnas.1216967109 |
