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Virus Details


VHFID3952

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name MAPK3
HF Protein Name Mitogen-activated protein kinase 3
HF Function Essential for astrovirus replication
Uniprot ID P27361
Protein Sequence View Fasta Sequence
NCBI Gene ID 5595
Host Factor (HF) Name in Paper ERK1
Gene synonyms ERK1 PRKM3
Ensemble Gene ID ENSG00000102882
Ensemble Transcript ENST00000263025 [P27361-1];ENST00000322266 [P27361-2];ENST00000395199 [P27361-3];ENST00000395202 [P27361-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000165, GO:0000187, GO:0001784, GO:0001934, GO:0002741, GO:0004674, GO:0004707, GO:0004708, GO:0005524, GO:0005634, GO:0005635, GO:0005654, GO:0005737, GO:0005739, GO:0005769, GO:0005770, GO:0005794, GO:0005829, GO:0005856, GO:0005886, GO:0005901, GO:0005925, GO:0006361, GO:0006468, GO:0006915, GO:0006975, GO:0007049, GO:0007411, GO:0008543, GO:0009636, GO:0010628, GO:0010759, GO:0014066, GO:0016032, GO:0016301, GO:0016310, GO:0018105, GO:0019233, GO:0019369, GO:0019902, GO:0030168, GO:0030278, GO:0030509, GO:0030641, GO:0030878, GO:0031143, GO:0031281, GO:0031663, GO:0032212, GO:0032872, GO:0033129, GO:0034198, GO:0034614, GO:0035066, GO:0038083, GO:0038095, GO:0038096, GO:0042473, GO:0042802, GO:0043330, GO:0045727, GO:0045944, GO:0048538, GO:0051090, GO:0051216, GO:0051403, GO:0051493, GO:0051973, GO:0060020, GO:0060324, GO:0060397, GO:0060425, GO:0060440, GO:0061308, GO:0065003, GO:0070062, GO:0070371, GO:0070374, GO:0070498, GO:0070849, GO:0071260, GO:0071276, GO:0071356, GO:0,
MINT ID P27361
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 601795
PANTHER ID N.A.
PDB ID(s) 2ZOQ, 4QTB,
pfam ID PF00069,
Drug Bank ID DB04604, DB01169, DB02733, DB00605,
ChEMBL ID CHEMBL3385
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human astrovirus
Virus Short Name HAstV
Order Nidovirales
Virus Family Astroviridae
Virus Subfamily N.A.
Genus Mamastrovirus
Species Human astrovirus
Host Human, mammals
Cell Tropism Enterocytes
Associated Disease Infantile gastroenteritis
Mode of Transmission Fecal-oral
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/positive-sense-rna-viruses-2011/w/posrna_viruses/247/astroviridae
Virus Host DB link N.A.

Publication Information

Paper Title Suppression of Astrovirus Replication by an ERK1/2 Inhibitor
Author's Name Lindsey A. Moser and Stacey Schultz-Cherry
Journal Name Journal Of Virology
Pubmed ID 18508903
Abstract Human astroviruses are nonenveloped, positive-sense single-strand RNA viruses associated with self-limiting diarrhea. Although they are recognized as a leading cause of disease in young children, the cellular factors involved in astrovirus replication are not well defined. The extracellular signal-regulated kinase (ERK) pathway has been shown to regulate many viral infections, but its role during astrovirus infection is unknown. In this report, we show that astrovirus activates ERK1/2 early in infection independently of replication. Inhibition of ERK activation with U0126, a specific ERK inhibitor, significantly reduced viral production. Investigations into the mechanism of ERK1/2 regulation revealed that all steps of the viral life cycle, including early and late protein expression as well as subgenomic and genomic RNA transcription, were diminished during U0126 treatment of monolayers. These data support a role for ERK1/2 in a postattachment step, although the precise mechanism remains under investigation.
Used Model Caco-2 cells
DOI 10.1128/JVI.02193-07