| Gene Name | IRF7 |
| HF Protein Name | Interferon regulatory factor 7 |
| HF Function | Antiviral protein |
| Uniprot ID | Q92985 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3665 |
| Host Factor (HF) Name in Paper | IRF-7 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000185507 |
| Ensemble Transcript | ENST00000330243 [Q92985-4];ENST00000348655 [Q92985-2];ENST00000397566 [Q92985-4];ENST00000397574 [Q92985-1];ENST00000469048 [Q92985-3];ENST00000533182 [Q92985-3];ENST00000612534 [Q92985-4];ENST00000621391 [Q92985-1];ENST00000632827 [Q92985-4];ENST00000633274 [Q92985-3];ENST00000633943 [Q92985-2];ENST00000634105 [Q92985-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000122, GO:0000979, GO:0000981, GO:0000982, GO:0002819, GO:0003677, GO:0005634, GO:0005654, GO:0005737, GO:0005829, GO:0006366, GO:0006974, GO:0009615, GO:0010008, GO:0016064, GO:0019043, GO:0032479, GO:0032481, GO:0032607, GO:0032608, GO:0032727, GO:0032728, GO:0034124, GO:0034127, GO:0035666, GO:0039530, GO:0045087, GO:0045351, GO:0045655, GO:0045893, GO:0045944, GO:0050776, GO:0051607, GO:0060333, GO:0060337, GO:0060340, GO:2000110, |
| MINT ID | Q92985 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605047 |
| PANTHER ID | PTHR11949 |
| PDB ID(s) | 2O61, |
| pfam ID | PF00605, PF10401, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 4 (Epstein-Barr virus) |
| Virus Short Name | EBV |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Gammaherpesvirinae |
| Genus | Lymphocryptovirus |
| Species | Human herpesvirus 4 |
| Host | Human, mammals |
| Cell Tropism | B lymphocytes, oral epithelial cells, latency: remains latent in cd19+ b cells |
| Associated Disease | Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc) |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Interferon Regulatory Factor 7 Is Negatively Regulated by the Epstein-Barr Virus Immediate-Early Gene, BZLF-1 |
| Author's Name | Angela M. Hahn, Leslie E. Huye, Shunbin Ning, Jennifer Webster-Cyriaque, and Joseph S. Pagano |
| Journal Name | Journal Of Virology |
| Pubmed ID | 16014964 |
| Abstract | Virus infection stimulates potent antiviral responses specifically, Epstein-Barr virus (EBV) infection induces and activates interferon regulatory factor 7 (IRF-7), which is essential for production of alpha/beta interferons (IFN-alpha/beta) and upregulates expression of Tap-2. Here we present evidence that during cytolytic viral replication the immediate-early EBV protein BZLF-1 counteracts effects of IRF-7 that are central to host antiviral responses. We initiated these studies by examining IRF-7 protein expression in vivo in lesions of hairy leukoplakia (HLP) in which there is abundant EBV replication but the expected inflammatory infiltrate is absent. This absence might predict that factors involved in the antiviral response are absent or inactive. First, we detected significant levels of IRF-7 in the nucleus, as well as in the cytoplasm, of cells in HLP lesions. IRF-7 activity in cell lines during cytolytic viral replication was examined by assay of the IRF-7-responsive promoters, IFN-alpha4, IFN-beta, and Tap-2, as well as of an IFN-stimulated response element (ISRE)-containing reporter construct. These reporter constructs showed consistent reduction of activity during lytic replication. Both endogenous and transiently expressed IRF-7 and EBV BZLF-1 proteins physically associate in cell culture, although BZLF-1 had no effect on the nuclear localization of IRF-7. However, IRF-7-dependent activity of the IFN-alpha4, IFN-beta, and Tap-2 promoters, as well as an ISRE promoter construct, was inhibited by BZLF-1. This inhibition occurred in the absence of other EBV proteins and was independent of IFN signaling. Expression of BZLF-1 also inhibited activation of IRF-7 by double-stranded RNA, as well as the activity of a constitutively active mutant form of IRF-7. Negative regulation of IRF-7 by BZLF-1 required the activation domain but not the DNA-binding domain of BZLF-1. Thus, EBV may subvert cellular antiviral responses and immune detection by blocking the activation of IFN-alpha4, IFN-beta, and Tap-2 by IRF-7 through the medium of BZLF-1 as a negative regulator. |
| Used Model | U4A cells lacking Jak-1,2fTGH and HEK293 cells |
| DOI | 10.1128/JVI.79.15.10040-10052.2005 |
