| Gene Name | TP53BP1 |
| HF Protein Name | TP53-binding protein 1 |
| HF Function | Association between Zta and 53BP1 is involved in the viral replication cycle |
| Uniprot ID | Q12888 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 7158 |
| Host Factor (HF) Name in Paper | 53BP1 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000067369 |
| Ensemble Transcript | ENST00000263801 [Q12888-1];ENST00000382044 [Q12888-2];ENST00000450115 [Q12888-3] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000077, GO:0000777, GO:0000784, GO:0001102, GO:0001104, GO:0002039, GO:0003684, GO:0005634, GO:0005654, GO:0005657, GO:0005737, GO:0006303, GO:0006351, GO:0006974, GO:0016604, GO:0016925, GO:0035064, GO:0035861, GO:0042162, GO:0045830, GO:0045893, GO:0045944, GO:0051091, GO:0051260, GO:0061649, GO:0071481, GO:1990391, GO:2000042, |
| MINT ID | Q12888 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605230 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG, 5J26, 5KGF, |
| pfam ID | PF09038, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL2424509 |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 4 (Epstein-Barr virus) |
| Virus Short Name | EBV |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Gammaherpesvirinae |
| Genus | Lymphocryptovirus |
| Species | Human herpesvirus 4 |
| Host | Human, mammals |
| Cell Tropism | B lymphocytes, oral epithelial cells, latency: remains latent in cd19+ b cells |
| Associated Disease | Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc) |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Functional Interaction between Epstein-Barr Virus Replication Protein Zta and Host DNA Damage Response Protein 53BP1 |
| Author's Name | Sarah G. Bailey, Elizabeth Verrall, Celine Schelcher, Alex Rhie, Aidan J. Doherty, and Alison J. Sinclair |
| Journal Name | Journal Of Virology |
| Pubmed ID | 19656881 |
| Abstract | Epstein-Barr virus (EBV human herpesvirus 4) poses major clinical problems worldwide. Following primary infection, EBV enters a form of long-lived latency in B lymphocytes, expressing few viral genes, and it persists for the lifetime of the host with sporadic bursts of viral replication. The switch between latency and replication is governed by the action of a multifunctional viral protein Zta (also called BZLF1, ZEBRA, and Z). Using a global proteomic approach, we identified a host DNA damage repair protein that specifically interacts with Zta: 53BP1. 53BP1 is intimately connected with the ATM signal transduction pathway, which is activated during EBV replication. The interaction of 53BP1 with Zta requires the C-terminal ends of both proteins. A series of Zta mutants that show a wild-type ability to perform basic functions of Zta, such as dimer formation, interaction with DNA, and the transactivation of viral genes, were shown to have lost the ability to induce the viral lytic cycle. Each of these mutants also is compromised in the C-terminal region for interaction with 53BP1. In addition, the knockdown of 53BP1 expression reduced viral replication, suggesting that the association between Zta and 53BP1 is involved in the viral replication cycle. |
| Used Model | 293T and HeLa cells |
| DOI | 10.1128/JVI.00512-09 |
