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Virus Details


VHFID3968

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name BRD4
HF Protein Name Bromodomain-containing protein 4
HF Function EBNA1 interacts with Brd4 and facilitates transcriptional activation by EBNA1 from the FR element
Uniprot ID O60885
Protein Sequence View Fasta Sequence
NCBI Gene ID 23476
Host Factor (HF) Name in Paper BRD4
Gene synonyms HUNK1
Ensemble Gene ID ENSG00000141867
Ensemble Transcript ENST00000263377 [O60885-1];ENST00000360016 [O60885-3];ENST00000371835 [O60885-2]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000083, GO:0000794, GO:0000993, GO:0002039, GO:0003682, GO:0005634, GO:0005654, GO:0005694, GO:0005829, GO:0006325, GO:0006338, GO:0006351, GO:0006974, GO:0010971, GO:0016032, GO:0032968, GO:0043123, GO:0045944, GO:0050727, GO:0070577, GO:1901407, GO:2000002,
MINT ID O60885
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 608749
PANTHER ID N.A.
PDB ID(s) 2I8N, 2LSP, 2MJV, 2N3K, 2NCZ, 2ND0, 2ND1, 2NNU, 2OSS, 2OUO, 2YEL, 2YEM, 3MXF, 3P5O, 3SVF, 3SVG, 3U5J, 3U5K, 3U5L, 3UVW, 3UVX, 3UVY, 3UW9, 3ZYU, 4A9L, 4BJX, 4BW1, 4BW2, 4BW3, 4BW4, 4C66, 4C67, 4CFK, 4CFL, 4CL9, 4CLB, 4DON, 4E96, 4F3I, 4GPJ, 4HBV, 4HBW, 4HBX, 4HBY, 4HXK, 4HXL, 4HXM, 4HXN, 4HXO, 4HXP, 4HXR, 4HXS, 4IOO, 4IOQ, 4IOR, 4J0R, 4J0S, 4J3I, 4KV1, 4KV4, 4LR6, 4LRG, 4LYI, 4LYS, 4LYW, 4LZR, 4LZS, 4MEN, 4MEO, 4MEP, 4MEQ, 4MR3, 4MR4, 4NQM, 4NR8, 4NUC, 4NUD, 4NUE, 4O70, 4O71, 4O72, 4O74, 4O75, 4O76, 4O77, 4O78, 4O7A, 4O7B, 4O7C, 4O7E, 4O7F, 4OGI, 4OGJ, 4PCE, 4PCI, 4PS5, 4QB3, 4QR3, 4QR4, 4QR5, 4QZS, 4UIX, 4UIY, 4UIZ, 4UYD, 4WHW, 4WIV, 4X2I, 4XY9, 4XYA, 4YH3, 4YH4, 4Z1Q, 4Z1S, 4Z93, 4ZC9, 4ZW1, 5A5S, 5A85, 5ACY, 5AD2, 5AD3, 5BT4, 5CFW, 5COI, 5CP5, 5CPE, 5CQT, 5CRM, 5CRZ, 5CS8, 5CTL, 5CY9, 5D0C, 5D24, 5D25, 5D26, 5D3H, 5D3J, 5D3L, 5D3N, 5D3P, 5D3R, 5D3S, 5D3T, 5DLX, 5DLZ, 5DW2, 5DX4, 5E0R, 5EGU, 5EI4, 5EIS, 5F5Z, 5F60, 5F61, 5F62, 5F63, 5FBX, 5H21, 5HCL, 5HLS, 5HM0, 5HQ5, 5HQ6, 5HQ7, 5I80, 5I88, 5IGK, 5JWM, 5KDH, 5KHM, 5KJ0, 5KU3, 5LJ1, 5LJ2, 5LRQ, 5LUU, 5M39, 5M3A, 5MKZ, 5MLI, 5N2M, 5T35, 5TI2, 5TI3, 5TI4, 5TI5, 5TI6, 5TI7, 5U28, 5U2C, 5U2E, 5U2F, 5UEO, 5UEP, 5UEQ, 5UER, 5UES, 5UET, ,
pfam ID PF17035, PF17105, PF00439,
Drug Bank ID N.A.,
ChEMBL ID CHEMBL1163125
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human herpesvirus 4 (Epstein-Barr virus)
Virus Short Name EBV
Order Herpesvirales
Virus Family Herpesviridae
Virus Subfamily Gammaherpesvirinae
Genus Lymphocryptovirus
Species Human herpesvirus 4
Host Human, mammals
Cell Tropism B lymphocytes, oral epithelial cells, latency: remains latent in cd19+ b cells
Associated Disease Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc)
Mode of Transmission Contact, saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae

Publication Information

Paper Title The EBNA1 Protein of Epstein-Barr Virus Functionally Interacts with Brd4
Author's Name Ammy Lin, Shan Wang, Tin Nguyen, Kathy Shire, and Lori Frappier
Journal Name Journal Of Virology
Pubmed ID 18922874
Abstract The EBNA1 protein of Epstein-Barr virus (EBV) is essential for EBV latent infection in ensuring the replication and stable segregation of the EBV genomes and in activating the transcription of other EBV latency genes. We have tested the ability of four host proteins (Brd2, Brd4, DEK, and MeCP2) implicated in the segregation of papillomavirus and Kaposis sarcoma-associated herpesvirus to support EBNA1-mediated segregation of EBV-based plasmids in Saccharomyces cerevisiae. We found that Brd4 enabled EBNA1-mediated segregation while Brd2 and MeCP2 had a general stimulatory effect on plasmid maintenance. EBNA1 interacted with Brd4 in both yeast and human cells through N-terminal sequences previously shown to mediate transcriptional activation but not segregation. In keeping with this interaction site, silencing of Brd4 in human cells decreased transcriptional activation by EBNA1 but not the mitotic chromosome attachment of EBNA1 that is required for segregation. In addition, Brd4 was found to be preferentially localized to the FR enhancer element regulated by EBNA1, over other EBV sequences, in latently EBV-infected cells. The results indicate that EBNA1 can functionally interact with Brd4 in native and heterologous systems and that this interaction facilitates transcriptional activation by EBNA1 from the FR element.
Used Model yest two hybrid system
DOI 10.1128/JVI.01680-08