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Virus Details


VHFID3969

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name NRP1
HF Protein Name Neuropilin-1
HF Function Virus entry factor
Uniprot ID O14786
Protein Sequence View Fasta Sequence
NCBI Gene ID 8829
Host Factor (HF) Name in Paper Neuropilin 1
Gene synonyms NRP VEGF165R
Ensemble Gene ID ENSG00000099250
Ensemble Transcript ENST00000265371 [O14786-1];ENST00000374821 [O14786-3];ENST00000374822 [O14786-2];ENST00000374867 [O14786-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001525, GO:0001569, GO:0001764, GO:0001938, GO:0002040, GO:0002042, GO:0002116, GO:0003148, GO:0005021, GO:0005096, GO:0005615, GO:0005769, GO:0005829, GO:0005883, GO:0005886, GO:0005925, GO:0006930, GO:0007165, GO:0007229, GO:0007267, GO:0007411, GO:0007413, GO:0008201, GO:0009611, GO:0009887, GO:0009986, GO:0010595, GO:0014911, GO:0015026, GO:0016021, GO:0017154, GO:0019838, GO:0019901, GO:0019955, GO:0021612, GO:0021637, GO:0021649, GO:0021675, GO:0021785, GO:0021828, GO:0030424, GO:0030426, GO:0031290, GO:0031410, GO:0031532, GO:0032489, GO:0034446, GO:0035729, GO:0035767, GO:0035924, GO:0036486, GO:0038085, GO:0038189, GO:0038190, GO:0042327, GO:0043005, GO:0043025, GO:0043235, GO:0043524, GO:0043542, GO:0046872, GO:0048008, GO:0048010, GO:0048012, GO:0048842, GO:0048843, GO:0048844, GO:0048846, GO:0050731, GO:0050918, GO:0051491, GO:0051496, GO:0051894, GO:0060301, GO:0060385, GO:0060627, GO:0060666, GO:0060978, GO:0060982, GO:0061299, GO:0061441, GO:0061549, GO:0061551, GO:0,
MINT ID O14786
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 602069
PANTHER ID PTHR44185;PTHR44185:SF1
PDB ID(s) 1KEX, 2QQI, 2QQM, 2QQN, 3I97, 4DEQ, 4RN5, 5C7G, 5IJR, 5IYY, 5J1X, 5JGI, 5JGQ, 5JHK, 5L73,
pfam ID PF00431, PF11980, PF00754, PF00629,
Drug Bank ID DB00039, DB04895,
ChEMBL ID CHEMBL5174
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human herpesvirus 4 (Epstein-Barr virus)
Virus Short Name EBV
Order Herpesvirales
Virus Family Herpesviridae
Virus Subfamily Gammaherpesvirinae
Genus Lymphocryptovirus
Species Human herpesvirus 4
Host Human, mammals
Cell Tropism B lymphocytes, oral epithelial cells, latency: remains latent in cd19+ b cells
Associated Disease Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc)
Mode of Transmission Contact, saliva
VIPR DB link http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae

Publication Information

Paper Title Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
Author's Name Hong-Bo Wang, Hua Zhang, Jing-Ping Zhang, Yan Li, Bo Zhao, Guo-Kai Feng, Yong Du, Dan Xiong, Qian Zhong, Wan-Li Liu, Huamao Du, Man-Zhi Li, Wen-Lin Huang, Sai Wah Tsao, Lindsey Hutt-Fletcher, Yi-Xin Zeng, Elliott Kieff & Mu-Sheng Zeng
Journal Name Nature Communications
Pubmed ID 25670642
Abstract Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both B and epithelial cells, and determines EBV susceptibility of non-B cells. Here we show that neuropilin 1 (NRP1) directly interacts with EBV gB(23-431). Either knockdown of NRP1 or pretreatment of EBV with soluble NRP1 suppresses EBV infection. Upregulation of NRP1 by overexpression or EGF treatment enhances EBV infection. However, NRP2, the homologue of NRP1, impairs EBV infection. EBV enters nasopharyngeal epithelial cells through NRP1-facilitated internalization and fusion, and through macropinocytosis and lipid raft-dependent endocytosis. NRP1 partially mediates EBV-activated EGFR/RAS/ERK signalling, and NRP1-dependent receptor tyrosine kinase (RTK) signalling promotes EBV infection. Taken together, NRP1 is identified as an EBV entry factor that cooperatively activates RTK signalling, which subsequently promotes EBV infection in nasopharyngeal epithelial cells.
Used Model NPEC03,SUNE1, SUNE2, 6-10B, CNE1, CNE2 and HNE1cells
DOI 10.1038/ncomms7240