| Gene Name | CR1 |
| HF Protein Name | Complement receptor type 1 |
| HF Function | Essential for virus entry |
| Uniprot ID | P17927 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 1378 |
| Host Factor (HF) Name in Paper | CD35 |
| Gene synonyms | C3BR |
| Ensemble Gene ID | ENSG00000203710 |
| Ensemble Transcript | ENST00000367051;ENST00000367053;ENST00000400960 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0001851, GO:0001855, GO:0001861, GO:0004877, GO:0005886, GO:0005887, GO:0006958, GO:0009986, GO:0030449, GO:0030667, GO:0043312, GO:0045087, GO:0045589, GO:0045957, GO:0045959, GO:0070062, GO:0101003, GO:1900004, GO:1900005, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 120620 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1GKG, 1GKN, 1GOP, 1PPQ, 2MCY, 2MCZ, 2Q7Z, 5FO9, |
| pfam ID | PF00084, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 4 (Epstein-Barr virus) |
| Virus Short Name | EBV |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Gammaherpesvirinae |
| Genus | Lymphocryptovirus |
| Species | Human herpesvirus 4 |
| Host | Human, mammals |
| Cell Tropism | B lymphocytes, oral epithelial cells, latency: remains latent in cd19+ b cells |
| Associated Disease | Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc) |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Human Complement Receptor Type 1/CD35 is an Epstein-Barr Virus Receptor |
| Author's Name | Javier G. Ogembo, Lakshmi Kannan, Ionita Ghiran, Anne Nicholson-Weller, Robert Finberg, George C. Tsokos and Joyce D. Fingeroth |
| Journal Name | Cell Reports |
| Pubmed ID | 23416052 |
| Abstract | Epstein-Barr virus (EBV) attachment to primary B cells initiates virus entry. Although CD21 is the only known receptor for EBVgp350/220, a recent report documents EBV-infected B cells from a patient genetically deficient in CD21. On normal resting B cells, CD21 forms two membrane complexes: one with CD19 and another with CD35. Whereas the CD21/CD19 complex is widely retained on immortalized and B cell tumor lines, the related complement-regulatory protein CD35 is lost. To determine the role(s) of CD35 in initial infection, we transduced a CD21-negative pre-B cell and myeloid leukemia line with CD35, CD21, or both. Cells expressing CD35 alone bound gp350/220 and became latently infected when the fusion receptor HLA II was coexpressed. Temporal, biophysical, and structural characteristics of CD35-mediated infection were distinct from CD21. Identification of CD35 as an EBV receptor uncovers a salient role in primary infection, addresses unsettled questions of virus tropism, and underscores the importance of EBVgp350/220 for vaccine development. |
| Used Model | CD21 cells |
| DOI | 10.1016/j.celrep.2013.01.023 |
