| Gene Name | ORC2 |
| HF Protein Name | Origin recognition complex subunit 2 |
| HF Function | Essential for virus replication |
| Uniprot ID | Q13416 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4999 |
| Host Factor (HF) Name in Paper | ORC2 |
| Gene synonyms | ORC2L |
| Ensemble Gene ID | ENSG00000115942 |
| Ensemble Transcript | ENST00000234296 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000082, GO:0000122, GO:0000784, GO:0000792, GO:0000808, GO:0000939, GO:0003688, GO:0005634, GO:0005654, GO:0005664, GO:0005813, GO:0006260, GO:0006270, GO:0016020, |
| MINT ID | Q13416 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 601182 |
| PANTHER ID | PTHR14052 |
| PDB ID(s) | 5C8H, 5UJ8, 5UJM, |
| pfam ID | PF04084, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human herpesvirus 4 (Epstein-Barr virus) |
| Virus Short Name | EBV |
| Order | Herpesvirales |
| Virus Family | Herpesviridae |
| Virus Subfamily | Gammaherpesvirinae |
| Genus | Lymphocryptovirus |
| Species | Human herpesvirus 4 |
| Host | Human, mammals |
| Cell Tropism | B lymphocytes, oral epithelial cells, latency: remains latent in cd19+ b cells |
| Associated Disease | Mononucleosis, associated with environemental diseases: burkitt?s lymphoma nasopharyngeal carcinoma (npc) |
| Mode of Transmission | Contact, saliva |
| VIPR DB link | http://www.viprbrc.org/brc/vipr_allSpecies_search.do?method=SubmitForm&decorator=herpes |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/91/herpesviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Herpesviridae |
| Paper Title | Replication from oriP of Epstein-Barr virus requires human ORC and is inhibited by geminin |
| Author's Name | Dhar SK, Yoshida K, Machida Y, Khaira P, Chaudhuri B, Wohlschlegel JA, Leffak M, Yates J, Dutta A. |
| Journal Name | cell |
| Pubmed ID | 11509178 |
| Abstract | A hypomorphic mutation made in the ORC2 gene of a human cancer cell line through homologous recombination decreased Orc2 protein levels by 90%. The G1 phase of the cell cycle was prolonged, but there was no effect on the utilization of either the c-Myc or beta-globin cellular origins of replication. Cells carrying this mutation failed to support the replication of a plasmid bearing the oriPreplicator of Epstein Barr virus (EBV), and this defect was rescued by reintroduction of Orc2. Orc2 specifically associates with oriP in cells, most likely through its interaction with EBNA1. Geminin, an inhibitor of the mammalian replication initiation complex, inhibits replication from oriP. Therefore, ORC and the human replication initiation apparatus is required for replication from a viral origin of replication. |
| Used Model | B cells |
| DOI | 10.1016/S0092-8674(01)00458-5 |
