| Gene Name | CD46 |
| HF Protein Name | Membrane cofactor protein |
| HF Function | Receptor for viral entry |
| Uniprot ID | P15529 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 4179 |
| Host Factor (HF) Name in Paper | CD46 |
| Gene synonyms | MCP MIC10 |
| Ensemble Gene ID | ENSG00000117335 |
| Ensemble Transcript | ENST00000322875 [P15529-2];ENST00000322918 [P15529-9];ENST00000354848 [P15529-3];ENST00000357714 [P15529-4];ENST00000358170 [P15529-1];ENST00000360212 [P15529-7];ENST00000367041 [P15529-12];ENST00000367042 [P15529-11];ENST00000367047 [P15529-16];ENST00000480003 [P15529-6] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0002079, GO:0002250, GO:0002456, GO:0004872, GO:0005886, GO:0005887, GO:0005925, GO:0006958, GO:0007338, GO:0008593, GO:0009986, GO:0010628, GO:0010629, GO:0030449, GO:0032613, GO:0032733, GO:0035581, GO:0042102, GO:0043382, GO:0045087, GO:0045296, GO:0045591, GO:0070062, GO:0071636, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 120920 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1CKL, 1HR4, 2O39, 3INB, 3L89, 3O8E, 5FO8, |
| pfam ID | PF00084, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human adenovirus 3 |
| Virus Short Name | HAdV-3 |
| Order | Unassigned |
| Virus Family | Adenoviridae |
| Virus Subfamily | N.A. |
| Genus | Mastadenovirus |
| Species | Human mastadenovirus B |
| Host | Human, mammals |
| Cell Tropism | Epithelial cells |
| Associated Disease | Very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. usually mild respiratory, gastrointestinal and eye infections. |
| Mode of Transmission | Respiratory, fecal-oral |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/93/adenoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Adenoviridae |
| Paper Title | CD46 is a cellular receptor for group B adenoviruses |
| Author's Name | Anuj Gaggar, Dmitry M Shayakhmetov and Andre Lieber |
| Journal Name | Nature Medicine |
| Pubmed ID | 14566335 |
| Abstract | Group B adenoviruses, a subgenus of human Adenoviridae, are associated with a variety of often-fatal illnesses in immunocompromised individuals, including bone marrow transplant recipients and cancer and AIDS patients. Recently, group B adenovirus derivatives have gained interest as attractive gene therapy vectors because they can transduce target tissues, such as hematopoietic stem cells, dendritic cells and malignant tumor cells, that are refractory to infection by commonly used adenoviral vectors. Whereas many adenoviruses infect cells through the coxsackievirus and adenovirus receptor (CAR), group B adenoviruses use an alternate, as-yet-unidentified cellular attachment receptor. Using mass spectrometric analysis of proteins interacting with a group B fiber, we identified human CD46 as a cellular attachment receptor for most group B adenoviruses. We show that ectopic expression of human CD46 rendered nonhuman cells susceptible to infection with group B viruses in vitro and in vivo. In addition, both siRNA-mediated knockdown of CD46 and a soluble form of CD46 blocked infection of human cell lines and primary human cells. The discovery that group B adenoviruses use CD46, a ubiquitously expressed complement regulatory protein, as a cellular attachment receptor elucidates the diverse clinical manifestation of group B virus infections, and bears directly on the application of these vectors for gene therapy. |
| Used Model | Hela and CHO cells |
| DOI | 10.1038/nm952 |
