| Gene Name | CD86 |
| HF Protein Name | T-lymphocyte activation antigen CD86 |
| HF Function | Cellular attachment receptors for adenovirus |
| Uniprot ID | P42081 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 942 |
| Host Factor (HF) Name in Paper | CD86 |
| Gene synonyms | CD28LG2 |
| Ensemble Gene ID | ENSG00000114013 |
| Ensemble Transcript | ENST00000264468 [P42081-4];ENST00000330540 [P42081-1];ENST00000393627 [P42081-3];ENST00000469710 [P42081-6];ENST00000493101 [P42081-5] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001618, GO:0002250, GO:0004872, GO:0005886, GO:0006955, GO:0008284, GO:0009986, GO:0015026, GO:0016021, GO:0019221, GO:0031295, GO:0043017, GO:0045086, GO:0045404, GO:0045630, GO:0045893, GO:0046934, GO:0051897, GO:0070062, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 601020 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1I85, 1NCN, |
| pfam ID | PF13895, PF07686, |
| Drug Bank ID | DB01281, DB00098, DB06681, |
| ChEMBL ID | CHEMBL2364156 |
| Organism | Homo sapiens (Human) |
| Virus Name | Human adenovirus 3 |
| Virus Short Name | HAdV-3 |
| Order | Unassigned |
| Virus Family | Adenoviridae |
| Virus Subfamily | N.A. |
| Genus | Mastadenovirus |
| Species | Human mastadenovirus B |
| Host | Human, mammals |
| Cell Tropism | Epithelial cells |
| Associated Disease | Very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. usually mild respiratory, gastrointestinal and eye infections. |
| Mode of Transmission | Respiratory, fecal-oral |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/93/adenoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Adenoviridae |
| Paper Title | Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors |
| Author's Name | Joshua J. Short, Chenthamarakshan Vasu, Mark J. Holterman, David T. Curiel and Alexander Pereboev |
| Journal Name | Virus Research |
| Pubmed ID | 16920215 |
| Abstract | Alternate serotypes of adenovirus (Ad), including Ads of species B, are being explored to circumvent the disadvantages of Ad serotype 5 gene delivery vectors. Whereas the majority of human Ads utilize the Coxsackievirus and adenovirus receptor (CAR), none of the Ad species B use CAR. Ad species B is further divided into two subspecies, B1 and B2, and utilizes at least two classes of receptors: common Ad species B receptors and B2 specific receptors. CD46 has been implicated as a B2-specific receptor. Ad serotype 3 (Ad3), a member of B1, utilizes CD80 and CD86 as cellular attachment receptors. The receptor-interacting Ad fiber-knob domain is highly homologous among species B Ads. We hypothesized that other members of Ad species B may utilize CD80 and CD86 as cellular attachment receptors. All tested species B members showed specific binding to cells expressing CD80 and CD86, and the Ad fiber-knob domain from both B1 and B2 Ad efficiently blocked CD80- and CD86-mediated infection of Ad3 vectors. Members of both B1 and B2 demonstrated CD80- and CD86-specific infection of CHO cells expressing CD80 and CD86. Therefore, all of the members of Ad species B utilize CD80 and CD86 for infection of cells. |
| Used Model | CHO cells |
| DOI | 10.1016/j.virusres.2006.07.009 |
