| Gene Name | TCOF1 |
| HF Protein Name | Treacle protein |
| HF Function | Required for protein recruitment and efficient Ad5 replication |
| Uniprot ID | Q13428 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 6949 |
| Host Factor (HF) Name in Paper | TCOF1 |
| Gene synonyms | N.A. |
| Ensemble Gene ID | ENSG00000070814 |
| Ensemble Transcript | ENST00000323668 [Q13428-2];ENST00000377797 [Q13428-1];ENST00000394269 [Q13428-5];ENST00000439160 [Q13428-7];ENST00000445265 [Q13428-8];ENST00000504761 [Q13428-1] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0001042, GO:0001501, GO:0001650, GO:0003723, GO:0005215, GO:0005634, GO:0005730, GO:0005829, GO:0006417, GO:0014029, GO:0014032, GO:0046982, GO:0097110, |
| MINT ID | Q13428 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 154500 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF03546, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human adenovirus 3 |
| Virus Short Name | HAdV-5 |
| Order | Unassigned |
| Virus Family | Adenoviridae |
| Virus Subfamily | N.A. |
| Genus | Mastadenovirus |
| Species | Human mastadenovirus C |
| Host | Human, mammals |
| Cell Tropism | Epithelial cells |
| Associated Disease | Very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. usually mild respiratory, gastrointestinal and eye infections. |
| Mode of Transmission | Respiratory, fecal-oral |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/93/adenoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Adenoviridae |
| Paper Title | Identifying host factors associated with DNA replicated during virus infection |
| Author's Name | Emigdio D. Reyes, Katarzyna Kulej, Neha J. Pancholi, Lisa N. Akhtar, Daphne C. Avgousti, Eui Tae Kim, Daniel K. Bricker, Lynn A. Spruce, Sarah A. Koniski, Steven H. Seeholzer, Stuart N. Isaacs, Benjamin A. Garcia, and Matthew D. Weitzman |
| Journal Name | Molecular and Cellular Proteomics |
| Pubmed ID | 28972080 |
| Abstract | Viral DNA genomes replicating in cells encounter a myriad of host factors that facilitate or hinder viral replication. Viral proteins expressed early during infection modulate host factors interacting with viral genomes, recruiting proteins to promote viral replication, and limiting access to antiviral repressors. Although some host factors manipulated by viruses have been identified, we have limited knowledge of pathways exploited during infection and how these differ between viruses. To identify cellular processes manipulated during viral replication, we defined proteomes associated with viral genomes during infection with adenovirus, herpes simplex virus and vaccinia virus. We compared enrichment of host factors between virus proteomes and confirmed association with viral genomes and replication compartments. Using adenovirus as an illustrative example, we uncovered host factors deactivated by early viral proteins, and identified a subgroup of nucleolar proteins that aid virus replication. Our data sets provide valuable resources of virus-host interactions that affect proteins on viral genomes. |
| Used Model | U2OS cells |
| DOI | 10.1074/mcp.M117.067116 |
