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Virus Details


VHFID4957

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name F10
HF Protein Name Coagulation factor X
HF Function Activates innate immunity against adenovirus
Uniprot ID P00742
Protein Sequence View Fasta Sequence
NCBI Gene ID 2159
Host Factor (HF) Name in Paper Coagulation factor X (FX)
Gene synonyms N.A.
Ensemble Gene ID ENSG00000126218
Ensemble Transcript ENST00000375559
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0004252, GO:0005509, GO:0005543, GO:0005576, GO:0005788, GO:0005796, GO:0005886, GO:0006465, GO:0006888, GO:0007596, GO:0007597, GO:0007598, GO:0017187, GO:0030335, GO:0031233, GO:0051897,
MINT ID P00742
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 227600
PANTHER ID N.A.
PDB ID(s) 1C5M, 1EZQ, 1F0R, 1F0S, 1FAX, 1FJS, 1FXY, 1G2L, 1G2M, 1HCG, 1IOE, 1IQE, 1IQF, 1IQG, 1IQH, 1IQI, 1IQJ, 1IQK, 1IQL, 1IQM, 1IQN, 1KSN, 1LPG, 1LPK, 1LPZ, 1LQD, 1MQ5, 1MQ6, 1MSX, 1NFU, 1NFW, 1NFX, 1NFY, 1NL8, 1P0S, 1V3X, 1WU1, 1XKA, 1XKB, 1Z6E, 2BMG, 2BOH, 2BOK, 2BQ6, 2BQ7, 2BQW, 2CJI, 2D1J, 2EI6, 2EI7, 2EI8, 2FZZ, 2G00, 2GD4, 2H9E, 2J2U, 2J34, 2J38, 2J4I, 2J94, 2J95, 2JKH, 2P16, 2P3F, 2P3T, 2P3U, 2P93, 2P94, 2P95, 2PHB, 2PR3, 2Q1J, 2RA0, 2UWL, 2UWO, 2UWP, 2VH0, 2VH6, 2VVC, 2VVU, 2VVV, 2VWL, 2VWM, 2VWN, 2VWO, 2W26, 2W3I, 2W3K, 2WYG, 2WYJ, 2XBV, 2XBW, 2XBX, 2XBY, 2XC0, 2XC4, 2XC5, 2Y5F, 2Y5G, 2Y5H, 2Y7X, 2Y7Z, 2Y80, 2Y81, 2Y82, 3CEN, 3CS7, 3ENS, 3FFG, 3HPT, 3IIT, 3K9X, 3KL6, 3KQB, 3KQC, 3KQD, 3KQE, 3LIW, 3M36, 3M37, 3Q3K, 3SW2, 3TK5, 3TK6, 4A7I, 4BTI, 4BTT, 4BTU, 4Y6D, 4Y71, 4Y76, 4Y79, 4Y7A, 4Y7B, 4ZH8, 4ZHA, 5JQY, 5JTC, 5JZ8, 5JZU, 5JZZ, 5K0H,
pfam ID PF00008, PF00594, PF00089,
Drug Bank ID DB07211, DB08746, DB07974, DB07277, DB07278, DB08487, DB08495, DB04673, DB08745, DB08173, DB07872, DB07843, DB07847, DB07844, DB00025, DB06605, DB00100, DB13150, DB00036, DB09075, DB01225, DB00569, DB03847, DB01109, DB05713, DB00170, DB07973, DB07800, DB06228, DB05362,
ChEMBL ID CHEMBL244
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human adenovirus 3
Virus Short Name HAdV-5
Order Unassigned
Virus Family Adenoviridae
Virus Subfamily N.A.
Genus Mastadenovirus
Species Human mastadenovirus C
Host Human, mammals
Cell Tropism Epithelial cells
Associated Disease Very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. usually mild respiratory, gastrointestinal and eye infections.
Mode of Transmission Respiratory, fecal-oral
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/93/adenoviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Adenoviridae

Publication Information

Paper Title Coagulation Factor X Activates Innate Immunity to Human Species C Adenovirus
Author's Name Konstantin Doronin, Justin W. Flat, Nelson C. Di Paolo, Reeti Khare, Oleksandr Kalyuzhniy, Mauro Acchione, John P. Sumida, Umeharu Ohto, Toshiyuki Shimizu, Sachiko Akashi-Takamura, Kensuke Miyake, James W. MacDonald, Theo K. Bammler, Richard P. Beyer, Frederico M. Farin, Phoebe L. Stewart and Dmitry M. Shayakhmetov
Journal Name Science
Pubmed ID 23019612
Abstract Although coagulation factors play a role in host defense for "living fossils" such as horseshoe crabs, the role of the coagulation system in immunity in higher organisms remains unclear. We modeled the interface of human species C adenovirus (HAdv) interaction with coagulation factor X (FX) and introduced a mutation that abrogated formation of the HAdv-FX complex. In vivo genome-wide transcriptional profiling revealed that FX-binding-ablated virus failed to activate a distinct network of nuclear factor κB-dependent early-response genes that are activated by HAdv-FX complex downstream of TLR4/MyD88/TRIF/TRAF6 signaling. Our study implicates host factor "decoration" of the virus as a mechanism to trigger an innate immune sensor that responds to a misplacement of coagulation FX from the blood into intracellular macrophage compartments upon virus entry into the cell.
Used Model CHO-K1 cells
DOI 10.1126/science.1226625