| Gene Name | FAM111A |
| HF Protein Name | Protein FAM111A |
| HF Function | Essential for viral infection |
| Uniprot ID | Q96PZ2 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 63901 |
| Host Factor (HF) Name in Paper | FAM111A |
| Gene synonyms | KIAA1895 |
| Ensemble Gene ID | ENSG00000166801 |
| Ensemble Transcript | ENST00000361723;ENST00000420244;ENST00000528737;ENST00000531147;ENST00000533703 |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000785, GO:0001650, GO:0005634, GO:0005737, GO:0006260, GO:0016032, GO:0045071, GO:0051607, |
| MINT ID | N.A. |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 127000 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | N.A., |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human adenovirus 3 |
| Virus Short Name | HAdV-5 |
| Order | Unassigned |
| Virus Family | Adenoviridae |
| Virus Subfamily | N.A. |
| Genus | Mastadenovirus |
| Species | Human mastadenovirus C |
| Host | Human, mammals |
| Cell Tropism | Epithelial cells |
| Associated Disease | Very common human infection, estimated to be responsible for between 2% and 5% of all respiratory infections. usually mild respiratory, gastrointestinal and eye infections. |
| Mode of Transmission | Respiratory, fecal-oral |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/93/adenoviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Adenoviridae |
| Paper Title | Identification of FAM111A as an SV40 host range restriction and adenovirus helper factor |
| Author's Name | Debrah A. Fine, Orit Rozenblatt-Rosen, Megha Padi, Anna Korkhin, Robert L. James, Guillaume Adelmant, Rosa Yoon, Luxuan Guo, Christian Berrios, Ying Zhang, Michael A. Calderwood, Soundarapandian Velmurgan, Jingwei Cheng, Jarrod A. Marto, David E. Hill, Michael E. Cusick, Marc Vidal, Laurence Florens, Michael P. Washburn, Larisa Litovchick, James A. DeCaprio |
| Journal Name | PLOS Pathogens |
| Pubmed ID | 23093934 |
| Abstract | The small genome of polyomaviruses encodes a limited number of proteins that are highly dependent on interactions with host cell proteins for efficient viral replication. The SV40 large T antigen (LT) contains several discrete functional domains including the LXCXE or RB-binding motif, the DNA binding and helicase domains that contribute to the viral life cycle. In addition, the LT C-terminal region contains the host range and adenovirus helper functions required for lytic infection in certain restrictive cell types. To understand how LT affects the host cell to facilitate viral replication, we expressed full-length or functional domains of LT in cells, identified interacting host proteins and carried out expression profiling. LT perturbed the expression of p53 target genes and subsets of cell-cycle dependent genes regulated by the DREAM and the B-Myb-MuvB complexes. Affinity purification of LT followed by mass spectrometry revealed a specific interaction between the LT C-terminal region and FAM111A, a previously uncharacterized protein. Depletion of FAM111A recapitulated the effects of heterologous expression of the LT C-terminal region, including increased viral gene expression and lytic infection of SV40 host range mutants and adenovirus replication in restrictive cells. FAM111A functions as a host range restriction factor that is specifically targeted by SV40 LT. |
| Used Model | U-2 OS,BSC40 and CV-1P cells |
| DOI | 10.1371/journal.ppat.1002949 |
