| Gene Name | TAX1BP1 |
| HF Protein Name | Tax1-binding protein 1 |
| HF Function | Essential viral replication |
| Uniprot ID | Q86VP1 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 8887 |
| Host Factor (HF) Name in Paper | Tax1BP1 |
| Gene synonyms | T6BP |
| Ensemble Gene ID | ENSG00000106052 |
| Ensemble Transcript | ENST00000265393 [Q86VP1-2];ENST00000396319 [Q86VP1-1];ENST00000433216 [Q86VP1-4];ENST00000543117 [Q86VP1-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0005829, GO:0006915, GO:0010803, GO:0019900, GO:0032088, GO:0032480, GO:0043066, GO:0046872, GO:0070062, |
| MINT ID | Q86VP1 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 605326 |
| PANTHER ID | N.A. |
| PDB ID(s) | 2M7Q, 4BMJ, 4NLH, 4Z4K, 4Z4M, 5AAS, |
| pfam ID | PF07888, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human papillomavirus type 16 |
| Virus Short Name | HPV16 |
| Order | Unassigned |
| Virus Family | Papillomaviridae |
| Virus Subfamily | N.A. |
| Genus | Alphapapillomavirus |
| Species | Human papillomavirus 16 |
| Host | Human, monkeys |
| Cell Tropism | Epithelial cells of skin, mucous membranes |
| Associated Disease | Malignant tumours |
| Mode of Transmission | Sexual, indirect and direct contact, auto-inoculation |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae |
| Paper Title | Tax1BP1 interacts with papillomavirus E2 and regulates E2-dependent transcription and stability |
| Author's Name | Xiaoyu Wang, Samisubbu R. Naidu, Francis Sverdrup and Elliot J. Androphy |
| Journal Name | Journal Of Virology |
| Pubmed ID | 19109394 |
| Abstract | The papillomavirus E2 proteins regulate viral replication, gene transcription, and genome maintenance by interacting with other viral and host proteins. From a yeast two-hybrid screen, we identified the cellular protein Tax1BP1 as a novel binding partner of human papillomavirus type 18 (HPV18) E2. Tax1BP1 also interacts with the HPV16 and bovine papillomavirus type 1 (BPV1) E2 proteins, with the C-terminal region of Tax1BP1 interacting with the N-terminal transactivation domain of BPV1 E2. Tax1BP1 complexes with p300 and acts synergistically as a coactivator with p300 to enhance E2-dependent transcription. Using chromatin immunoprecipitation assays, we show that Tax1BP1 and E2 localize to the long control region on the BPV1 genome. Tax1BP1 was recently reported to bind ubiquitin and to function as an essential component of an A20 ubiquitin-editing complex. We demonstrate that Tax1BP1 plays a role in the regulation of the steady-state level of E2 by preventing its proteasomal degradation. These studies provide new insights into the regulation of E2 functions. |
| Used Model | C33A cells |
| DOI | 10.1128/JVI.01791-08 |
