| Gene Name | TNFRSF1A |
| HF Protein Name | Tumor necrosis factor receptor superfamily member 1A |
| HF Function | Viral E6 Protein binds to Tumor Necrosis Factor (TNF) R1 and protects cells from TNF-induced Apoptosis |
| Uniprot ID | P19438 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 7132 |
| Host Factor (HF) Name in Paper | TNF R1 |
| Gene synonyms | TNFAR TNFR1 |
| Ensemble Gene ID | ENSG00000067182 |
| Ensemble Transcript | ENST00000162749 [P19438-1];ENST00000366159 [P19438-5] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000139, GO:0005031, GO:0005576, GO:0005615, GO:0005739, GO:0005886, GO:0005887, GO:0006693, GO:0006954, GO:0006955, GO:0007249, GO:0008625, GO:0008630, GO:0009986, GO:0010803, GO:0016032, GO:0019221, GO:0032496, GO:0033209, GO:0042127, GO:0042531, GO:0042742, GO:0042802, GO:0042981, GO:0043120, GO:0043123, GO:0043235, GO:0045121, GO:0045944, GO:0050728, GO:0050729, GO:0071260, GO:0071550, GO:0072659, GO:1903140, GO:2000304, |
| MINT ID | P19438 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 142680 |
| PANTHER ID | N.A. |
| PDB ID(s) | 1EXT, 1FT4, 1ICH, 1NCF, 1TNR, |
| pfam ID | PF00531, PF00020, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL3378 |
| Organism | Homo sapiens (Human) |
| Virus Name | Human papillomavirus type 16 |
| Virus Short Name | HPV16 |
| Order | Unassigned |
| Virus Family | Papillomaviridae |
| Virus Subfamily | N.A. |
| Genus | Alphapapillomavirus |
| Species | Human papillomavirus 16 |
| Host | Human, monkeys |
| Cell Tropism | Epithelial cells of skin, mucous membranes |
| Associated Disease | Malignant tumours |
| Mode of Transmission | Sexual, indirect and direct contact, auto-inoculation |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae |
| Paper Title | The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protectscells from TNF-induced apoptosis |
| Author's Name | Maria Filippova, Helen Song, Jodi L. Connolly, Terence S. Dermody, and Penelope J. Duerksen-Hughes |
| Journal Name | The Journal Of Biological Chemistry |
| Pubmed ID | 11934887 |
| Abstract | High risk strains of human papillomavirus (HPV), such as HPV 16, cause human cervical carcinoma. The E6 protein of HPV 16 mediates the rapid degradation of p53, although this is not the only function of E6 and cannot completely explain its transforming potential. Previous work in our laboratory has demonstrated that transfection of HPV 16 E6 into the tumor necrosis factor (TNF)-sensitive LM cell line protects expressing cells from TNF-induced apoptosis in a p53-independent manner, and the purpose of this study was to determine the molecular mechanism underlying this protection. Caspase 3 and caspase 8 activation were significantly reduced in E6-expressing cells, indicating that E6 acts early in the TNF apoptotic pathway. In fact, E6 binds directly to TNF R1, as shown both by co-immunoprecipitation and mammalian two-hybrid approaches. E6 requires the same C-terminal portion of TNF R1 for binding as does TNF R1-associated death domain, and TNF R1/TNF R1-associated death domain interactions are decreased in the presence of E6. HA-E6 also blocked cell death triggered by transfection of the death domain of TNF R1. Together, these results provide strong support for a model in which HPV E6 binding to TNF R1 interferes with formation of the death-inducing signaling complex and thus with transduction of proapoptotic signals. They also demonstrate that HPV, like several other viruses, has developed a method for evading the TNF-mediated host immune response. |
| Used Model | LM, U2OS, U937 , and NIH3T3 |
| DOI | 10.1074/jbc.M200113200 |
