| Gene Name | IFIT1 |
| HF Protein Name | Interferon-induced protein with tetratricopeptide repeats 1 |
| HF Function | Host Restriction factor |
| Uniprot ID | P09914 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 3434 |
| Host Factor (HF) Name in Paper | p56 |
| Gene synonyms | G10P1 IFI56 IFNAI1 ISG56 |
| Ensemble Gene ID | ENSG00000185745 |
| Ensemble Transcript | ENST00000371804 [P09914-1];ENST00000546318 [P09914-2] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0003723, GO:0005737, GO:0005829, GO:0009615, GO:0016032, GO:0019060, GO:0032091, GO:0043657, GO:0045070, GO:0045071, GO:0050689, GO:0051097, GO:0051607, GO:0060337, GO:0071357, GO:0071360, |
| MINT ID | P09914 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 147690 |
| PANTHER ID | PTHR10271:SF22 |
| PDB ID(s) | 4HOU, 5UDI, 5UDJ, 5UDK, 5UDL, 5W5H, 5W5I, |
| pfam ID | PF13181, |
| Drug Bank ID | N.A., |
| ChEMBL ID | N.A. |
| Organism | Homo sapiens (Human) |
| Virus Name | Human papillomavirus type 16 |
| Virus Short Name | HPV16 |
| Order | Unassigned |
| Virus Family | Papillomaviridae |
| Virus Subfamily | N.A. |
| Genus | Alphapapillomavirus |
| Species | Human papillomavirus 16 |
| Host | Human, monkeys |
| Cell Tropism | Epithelial cells of skin, mucous membranes |
| Associated Disease | Malignant tumours |
| Mode of Transmission | Sexual, indirect and direct contact, auto-inoculation |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae |
| Paper Title | The inhibitory action of P56 on select functions of E1 mediates interferon's effect on human papillomavirus DNA replication |
| Author's Name | Paramananda Saikia, Volker Fensterl, and Ganes C. Sen |
| Journal Name | Journal Of Virology |
| Pubmed ID | 20926571 |
| Abstract | The interferon (IFN)-induced protein P56 inhibits human papillomavirus (HPV) DNA replication by binding to HPV E1, which has several distinct functions in initiating viral DNA replication. Here, we determined that P56 inhibited HPV type 18 (HPV18) E1s DNA helicase activity, E2 binding, and HPV Ori sequence-specific DNA binding but not nonspecific DNA binding. We observed that deletion of a single amino acid, F399, produced an E1 mutant that could not bind P56. This E1 mutant retained its ability to support Ori DNA replication, but this activity was not inhibited by IFN, demonstrating that P56 is the principal executor of the anti-HPV action of IFN. |
| Used Model | BPV-transformed mouse cells |
| DOI | 10.1128/JVI.01194-10 |
