Virus Details


VHFID4978

Host Factor Information

Gene Name TP53
HF Protein Name Cellular tumor antigen p53
HF Function Host Restriction factor
Uniprot ID P04637
Protein Sequence View Fasta Sequence
NCBI Gene ID 7157
Host Factor (HF) Name in Paper p53
Gene synonyms P53
Ensemble Gene ID ENSG00000141510
Ensemble Transcript ENST00000269305 [P04637-1];ENST00000420246 [P04637-2];ENST00000445888 [P04637-1];ENST00000455263 [P04637-3];ENST00000504290 [P04637-9];ENST00000504937 [P04637-7];ENST00000510385 [P04637-8];ENST00000610292 [P04637-4];ENST00000610538 [P04637-6];ENST00000617185 [P04637-2];ENST00000619485 [P04637-4];ENST00000620739 [P04637-4];ENST00000622645 [P04637-5]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0000122, GO:0000733, GO:0000790, GO:0000978, GO:0000981, GO:0000990, GO:0001046, GO:0001074, GO:0001084, GO:0001085, GO:0001094, GO:0001228, GO:0002020, GO:0002039, GO:0003677, GO:0003682, GO:0003684, GO:0003700, GO:0003730, GO:0005507, GO:0005524, GO:0005622, GO:0005634, GO:0005654, GO:0005657, GO:0005730, GO:0005737, GO:0005739, GO:0005759, GO:0005783, GO:0005829, GO:0006284, GO:0006289, GO:0006355, GO:0006914, GO:0006974, GO:0006977, GO:0006978, GO:0006983, GO:0007050, GO:0007265, GO:0007275, GO:0007569, GO:0008104, GO:0008134, GO:0008270, GO:0008283, GO:0008285, GO:0008340, GO:0009299, GO:0010165, GO:0010332, GO:0010628, GO:0016032, GO:0016363, GO:0016579, GO:0016605, GO:0019221, GO:0019899, GO:0019901, GO:0019903, GO:0030154, GO:0030308, GO:0030330, GO:0030971, GO:0031065, GO:0031497, GO:0031571, GO:0031625, GO:0032461, GO:0032991, GO:0034613, GO:0034644, GO:0035035, GO:0035690, GO:0042149, GO:0042771, GO:0042802, GO:0042826, GO:0042981, GO:0043065, GO:0043066, GO:0043153, GO:0,
MINT ID P04637
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 133239
PANTHER ID PTHR11447
PDB ID(s) 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1JSP, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL, 1TSR, 1TUP, 1UOL, 1XQH, 1YC5, 1YCQ, 1YCR, 1YCS, 2AC0, 2ADY, 2AHI, 2ATA, 2B3G, 2BIM, 2BIN, 2BIO, 2BIP, 2BIQ, 2F1X, 2FEJ, 2FOJ, 2FOO, 2GS0, 2H1L, 2H2D, 2H2F, 2H4F, 2H4H, 2H4J, 2H59, 2J0Z, 2J10, 2J11, 2J1W, 2J1X, 2J1Y, 2J1Z, 2J20, 2J21, 2K8F, 2L14, 2LY4, 2MEJ, 2MWO, 2MWP, 2MWY, 2MZD, 2OCJ, 2PCX, 2RUK, 2VUK, 2WGX, 2X0U, 2X0V, 2X0W, 2XWR, 2YBG, 2YDR, 2Z5S, 2Z5T, 3D05, 3D06, 3D07, 3D08, 3D09, 3D0A, 3DAB, 3DAC, 3IGK, 3IGL, 3KMD, 3KZ8, 3LW1, 3OQ5, 3PDH, 3Q01, 3Q05, 3Q06, 3SAK, 3TG5, 3TS8, 3ZME, 4AGL, 4AGM, 4AGN, 4AGO, 4AGP, 4AGQ, 4BUZ, 4BV2, 4HFZ, 4HJE, 4IBQ, 4IBS, 4IBT, 4IBU, 4IBV, 4IBW, 4IBY, 4IBZ, 4IJT, 4KVP, 4LO9, 4LOE, 4LOF, 4MZI, 4MZR, 4QO1, 4RP6, 4RP7, 4X34, 4XR8, 4ZZJ, 5A7B, 5AB9, 5ABA, 5AOI, 5AOJ, 5AOK, 5AOL, 5AOM, 5BUA, 5ECG, 5G4M, 5G4N, 5G4O, 5HOU, 5HP0, 5HPD, 5LAP, 5LGY, 5MHC, 5MOC, 5OL0, 5UN8,
pfam ID PF00870, PF08563, PF07710,
Drug Bank ID DB08363, DB00945, DB05404,
ChEMBL ID CHEMBL4096
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human papillomavirus type 16
Virus Short Name HPV16
Order Unassigned
Virus Family Papillomaviridae
Virus Subfamily N.A.
Genus Alphapapillomavirus
Species Human papillomavirus 16
Host Human, monkeys
Cell Tropism Epithelial cells of skin, mucous membranes
Associated Disease Malignant tumours
Mode of Transmission Sexual, indirect and direct contact, auto-inoculation
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae

Publication Information

Paper Title p53 represses human papillomavirus type 16 DNA replication via the viral E2 protein
Author's Name Craig Brown, Anna M Kowalczyk, Ewan R Taylor, Iain M Morgan and Kevin Gaston
Journal Name Virology Journal
Pubmed ID 18190682
Abstract BACKGROUND: Human papillomavirus (HPV) DNA replication can be inhibited by the cellular tumour suppressor protein p53. However, the mechanism through which p53 inhibits viral replication and the role that this might play in the HPV life cycle are not known. The papillomavirus E2 protein is required for efficient HPV DNA replication and also regulates viral gene expression. E2 represses transcription of the HPV E6 and E7 oncogenes and can thereby modulate indirectly host cell proliferation and survival. In addition, the E2 protein from HPV 16 has been shown to bind p53 and to be capable of inducing apoptosis independently of E6 and E7.RESULTS: Here we use a panel of E2 mutants to confirm that mutations which block the induction of apoptosis via this E6/E7-independent pathway, have little or no effect on the induction of apoptosis by the E6/E7-dependent pathway. Although these mutations in E2 do not affect the ability of the protein to mediate HPV DNA replication, they do abrogate the repressive effects of p53 on the transcriptional activity of E2 and prevent the inhibition of E2-dependent HPV DNA replication by p53. CONCLUSION: These data suggest that p53 down-regulates HPV 16 DNA replication via the E2 protein.
Used Model Hela cells
DOI 10.1186/1743-422X-5-5