| Gene Name | FANCD2 |
| HF Protein Name | Fanconi anemia group D2 protein |
| HF Function | Host Restriction factor |
| Uniprot ID | Q9BXW9 |
| Protein Sequence | View Fasta Sequence |
| NCBI Gene ID | 2177 |
| Host Factor (HF) Name in Paper | FANCD2 |
| Gene synonyms | FACD |
| Ensemble Gene ID | ENSG00000144554 |
| Ensemble Transcript | ENST00000287647 [Q9BXW9-1];ENST00000383807 [Q9BXW9-2];ENST00000419585 [Q9BXW9-2];ENST00000431693 [Q9BXW9-4] |
| KEGG ID | Go to KEGG Database |
| Gene Ontology ID(s) | GO:0000793, GO:0005634, GO:0005654, GO:0005730, GO:0005829, GO:0006281, GO:0007129, GO:0007276, GO:0010332, GO:0016604, GO:0034599, GO:0036297, GO:0045589, GO:0048854, GO:0050727, GO:0051090, GO:0070182, GO:0097150, GO:2000348, |
| MINT ID | Q9BXW9 |
| STRING | Click to see interaction map |
| GWAS Analysis | Click to see gwas analysis |
| OMIM ID | 227646 |
| PANTHER ID | N.A. |
| PDB ID(s) | N.A., |
| pfam ID | PF14631, |
| Drug Bank ID | N.A., |
| ChEMBL ID | CHEMBL2157857 |
| Organism | Homo sapiens (Human) |
| Virus Name | Human papillomavirus type 16 |
| Virus Short Name | HPV16 |
| Order | Unassigned |
| Virus Family | Papillomaviridae |
| Virus Subfamily | N.A. |
| Genus | Alphapapillomavirus |
| Species | Human papillomavirus 16 |
| Host | Human, monkeys |
| Cell Tropism | Epithelial cells of skin, mucous membranes |
| Associated Disease | Malignant tumours |
| Mode of Transmission | Sexual, indirect and direct contact, auto-inoculation |
| VIPR DB link | N.A. |
| ICTV DB link | https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae |
| Virus Host DB link | http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae |
| Paper Title | The fanconi anemia pathway limits human papillomavirus replication |
| Author's Name | Elizabeth E. Hoskins, Richard J. Morreale, Stephen P. Werner, Jennifer M. Higginbotham, Laimonis A. Laimins, Paul F. Lambert, Darron R. Brown, Maura L. Gillison, Gerard J. Nuovo, David P. Witte, Mi-Ok Kim, Stella M. Davies, Parinda A. Mehta, Melinda Butsch Kovacic, Kathryn A. Wikenheiser-Brokamp, and Susanne I. Wells |
| Journal Name | Journal Of Virology |
| Pubmed ID | 22623785 |
| Abstract | High-risk human papillomaviruses (HPVs) deregulate epidermal differentiation and cause anogenital and head and neck squamous cell carcinomas (SCCs). The E7 gene is considered the predominant viral oncogene and drives proliferation and genome instability. While the implementation of routine screens has greatly reduced the incidence of cervical cancers which are almost exclusively HPV positive, the proportion of HPV-positive head and neck SCCs is on the rise. High levels of HPV oncogene expression and genome load are linked to disease progression, but genetic risk factors that regulate oncogene abundance and/or genome amplification remain poorly understood. Fanconi anemia (FA) is a genome instability syndrome characterized at least in part by extreme susceptibility to SCCs. FA results from mutations in one of 15 genes in the FA pathway, whose protein products assemble in the nucleus and play important roles in DNA damage repair. We report here that loss of FA pathway components FANCA and FANCD2 stimulates E7 protein accumulation in human keratinocytes and causes increased epithelial proliferation and basal cell layer expansion in the HPV-positive epidermis. Additionally, FANCD2 loss stimulates HPV genome amplification in differentiating cells, demonstrating that the intact FA pathway functions to restrict the HPV life cycle. These findings raise the possibility that FA genes suppress HPV infection and disease and suggest possible mechanism(s) for reported associations of HPV with an FA cohort in Brazil and for allelic variation of FA genes with HPV persistence in the general population. |
| Used Model | HFKs and NIKS cells |
| DOI | 10.1128/JVI.00408-12 |
