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Virus Details


VHFID4987

Host Factor Information

Pathogen Information

Publication Information

Host Factor Information

Gene Name ANXA2
HF Protein Name Annexin A2
HF Function Regulates the intracellular trafficking of virus
Uniprot ID P07355
Protein Sequence View Fasta Sequence
NCBI Gene ID 302
Host Factor (HF) Name in Paper AnxA2
Gene synonyms ANX2 ANX2L4 CAL1H LPC2D
Ensemble Gene ID ENSG00000182718
Ensemble Transcript ENST00000332680 [P07355-2];ENST00000396024 [P07355-1];ENST00000421017 [P07355-1];ENST00000451270 [P07355-1]
KEGG ID Go to KEGG Database
Gene Ontology ID(s) GO:0001525, GO:0001726, GO:0001765, GO:0001921, GO:0001934, GO:0002020, GO:0003723, GO:0005509, GO:0005544, GO:0005546, GO:0005576, GO:0005604, GO:0005615, GO:0005634, GO:0005737, GO:0005765, GO:0005768, GO:0005769, GO:0005811, GO:0005829, GO:0005886, GO:0005913, GO:0005938, GO:0006900, GO:0007589, GO:0008092, GO:0009986, GO:0016020, GO:0016323, GO:0017137, GO:0019834, GO:0019897, GO:0030199, GO:0030496, GO:0031012, GO:0031340, GO:0031902, GO:0031982, GO:0032804, GO:0035578, GO:0035722, GO:0035749, GO:0036035, GO:0042383, GO:0042470, GO:0042730, GO:0042802, GO:0043220, GO:0043312, GO:0044090, GO:0044147, GO:0044354, GO:0044548, GO:0044730, GO:0045121, GO:0048146, GO:0048306, GO:0048471, GO:0051290, GO:0052362, GO:0052405, GO:0070062, GO:0072659, GO:0097066, GO:0098641, GO:0098772, GO:1905581, GO:1905597, GO:1905599, GO:1905602, GO:1990667,
MINT ID P07355
STRING Click to see interaction map
GWAS Analysis Click to see gwas analysis
OMIM ID 151740
PANTHER ID PTHR10502:SF18
PDB ID(s) 1W7B, 1XJL, 2HYU, 2HYV, 2HYW, 4DRW, 4FTG, 4HRH, 5LPU, 5LPX, 5LQ0, 5LQ2, 5N7D, 5N7F, 5N7G,
pfam ID PF00191,
Drug Bank ID DB00031,
ChEMBL ID CHEMBL1764938
Organism Homo sapiens (Human)

Pathogen Information

Virus Name Human papillomavirus type 16
Virus Short Name HPV16
Order Unassigned
Virus Family Papillomaviridae
Virus Subfamily N.A.
Genus Alphapapillomavirus
Species Human papillomavirus 16
Host Human, monkeys
Cell Tropism Epithelial cells of skin, mucous membranes
Associated Disease Malignant tumours
Mode of Transmission Sexual, indirect and direct contact, auto-inoculation
VIPR DB link N.A.
ICTV DB link https://talk.ictvonline.org/ictv-reports/ictv_9th_report/dsdna-viruses-2011/w/dsdna_viruses/121/papillomaviridae
Virus Host DB link http://www.genome.jp/virushostdb/view/?virus_lineage=Papillomaviridae

Publication Information

Paper Title Annexin A2 and S100A10 regulate human papillomavirus type 16 entry and intracellular trafficking in human keratinocytes
Author's Name Agnieszka Dziduszko, Michelle A. Ozbun
Journal Name Journal Of Virology
Pubmed ID 23637395
Abstract Human papillomaviruses (HPVs) cause benign and malignant tumors of the mucosal and cutaneous epithelium. The initial events regulating HPV infection impact the establishment of viral persistence, which is requisite for malignant progression of HPV-infected lesions. However, the precise mechanisms involved in HPV entry into host cells, including the cellular factors regulating virus uptake, are not clearly defined. We show that HPV16 exposure to human keratinocytes initiates epidermal growth factor receptor (EGFR)-dependent Src protein kinase activation that results in phosphorylation and extracellular translocation of annexin A2 (AnxA2). HPV16 particles interact with AnxA2 in association with S100A10 as a heterotetramer at the cell surface in a Ca(2+)-dependent manner, and the interaction appears to involve heparan-sulfonated proteoglycans. We show multiple lines of evidence that this interaction promotes virus uptake into host cells. An antibody to AnxA2 prevents HPV16 internalization, whereas an antibody to S100A10 blocks infection at a late endosomal/lysosomal site. These results suggest that AnxA2 and S100A10 have separate roles during HPV16 binding, entry, and trafficking. Our data additionally imply that AnxA2 and S100A10 may be involved in regulating the intracellular trafficking of virus particles prior to nuclear delivery of the viral genome.
Used Model HaCaT and HEK-293T
DOI 10.1128/JVI.00519-13